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Mhc Myosin heavy chain [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35007, updated on 25-Nov-2025
Official Symbol
Mhcprovided by FlyBase
Official Full Name
Myosin heavy chainprovided by FlyBase
Primary source
FLYBASE:FBgn0264695
Locus tag
Dmel_CG17927
See related
AllianceGenome:FB:FBgn0264695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Bsh; CG17927; chr2L:16765388..16765564; chr2L:16781880..16782040; Dm II; Dmel\CG17927; DmMHC; DROMHC; DroMII; ifm(2)2; Ifm(2)2; ifm(2)RU1; Ifm(2)RU1; ifm(2)RU2; l(2)36Ae; l(2)k10423; l(2)M66; mhc; MHC; Mhc36B; mMHC; Mrp; MRP; MyHC; Myo; Myo6; Myosin; Nup; Sht; sMHC; Stp
Summary
Enables microfilament motor activity and protein homodimerization activity. A structural constituent of muscle. Involved in several processes, including actin cytoskeleton organization; adult somatic muscle development; and epithelial cell migration. Located in A band and polytene chromosome puff. Is expressed in several structures, including adult digestive system; anterior-posterior subdivision of organism; gut section; muscle cell; and muscle system. Used to study cardiomyopathy (multiple) and muscle tissue disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including cardiomyopathy (multiple); congenital heart disease (multiple); contractures, pterygia, and spondylocarpotarsal fusion syndrome (multiple); heart conduction disease (multiple); and muscle tissue disease (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1) and MYH3 (myosin heavy chain 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See Mhc in Genome Data Viewer
Location:
36B1-36B1; 2-53 cM
Exon count:
32
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16766566..16788766)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16766566..16788766)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Bub3 interacting GLEBS and Zinc finger domain protein Neighboring gene yellow-b Neighboring gene pickpocket 17 Neighboring gene Cytochrome b5-related Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. An alternative domain near the nucleotide-binding site of Drosophila muscle myosin affects ATPase kinetics. Miller BM, et al. J Mol Biol, 2005 Oct 14. PMID 16154586
  2. Analysis of the 5' end of the Drosophila muscle myosin heavy chain gene. Alternatively spliced transcripts initiate at a single site and intron locations are conserved compared to myosin genes of other organisms. Wassenberg DR 2nd, et al. J Biol Chem, 1987 Aug 5. PMID 3038896
  3. Mutations of the Drosophila myosin heavy-chain gene: effects on transcription, myosin accumulation, and muscle function. Mogami K, et al. Proc Natl Acad Sci U S A, 1986 Mar. PMID 3006049, Free PMC Article
  4. [An electron microscopic study of the structure of the indirect flight musculature at the pupal stage in the muscle mutant of Drosophila melanogaster]. Generalova MV, et al. Ontogenez, 1994 Nov-Dec. PMID 7777254
  5. Prolonged myosin binding increases muscle stiffness in Drosophila models of Freeman-Sheldon syndrome. Bell KM, et al. Biophys J, 2021 Mar 2. PMID 33524372, Free PMC Article

See all (646) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila.
    Title: Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila.
  2. Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism.
    Title: Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism.
  3. Alternative N-terminal regions of Drosophila myosin heavy chain II regulate communication of the purine binding loop with the essential light chain.
    Title: Alternative N-terminal regions of Drosophila myosin heavy chain II regulate communication of the purine binding loop with the essential light chain.
  4. Atypical Myosin Tunes Dendrite Arbor Subdivision.
    Title: Atypical Myosin Tunes Dendrite Arbor Subdivision.
  5. Hypertrophic cardiomyopathy causative mutation R249Q alters flight muscle contractility and flight performance.
    Title: The R249Q hypertrophic cardiomyopathy myosin mutation decreases contractility in Drosophila by impeding force production.
  6. Here we report the first x-ray crystal structure of an insect myosin: the D melanogaster skeletal muscle myosin II embryonic isoform (EMB). Using our system for recombinant expression of myosin heavy chain (MHC) proteins in whole transgenic flies, we prepared and crystallized stable proteolytic S1-like fragments containing the entire EMB motor domain bound to an essential light chain
    Title: X-ray Crystallographic and Molecular Dynamic Analyses of Drosophila melanogaster Embryonic Muscle Myosin Define Domains Responsible for Isoform-Specific Properties.
  7. Findings indicate that the Freeman Sheldon Syndrome (FSS) contracture syndrome mutations lead to muscle structural defects and functional deficits in Drosophila, possibly mediated by the reduced ATPase activity of the mutant Myosin heavy chain (MHC) proteins.
    Title: Myosin heavy chain mutations that cause Freeman-Sheldon syndrome lead to muscle structural and functional defects in Drosophila.
  8. Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension.
    Title: Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension.
  9. We conclude that MHC isoforms can alter FSA and hence cyclical power generation but that isoforms can only endow a muscle type with moderate FSA Highly SA muscle types, such as IFM, likely use a different or additional mechanism.
    Title: The Drosophila indirect flight muscle myosin heavy chain isoform is insufficient to transform the jump muscle into a highly stretch-activated muscle type.
  10. Introduction of a mutation (R759E) in the converter domain inhibits the steady-state ATPase of myosin S1, whereas an additional mutation in the relay domain (N509K) is able to restore the ATPase.
    Title: The Relay/Converter Interface Influences Hydrolysis of ATP by Skeletal Muscle Myosin II.
Submit: New GeneRIF Correction See all GeneRIFs (25)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables microfilament motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of muscle IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of muscle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in border follicle cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flight IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotion IEA
Inferred from Electronic Annotation
more info
  
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle thin filament assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myofibril assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myosin filament organization IEA
Inferred from Electronic Annotation
more info
  
involved_in myosin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IEA
Inferred from Electronic Annotation
more info
  
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of myosin II filament assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sarcomere organization IEA
Inferred from Electronic Annotation
more info
  
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in A band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in A band IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myofibril IEA
Inferred from Electronic Annotation
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myosin filament IEA
Inferred from Electronic Annotation
more info
  
located_in polytene chromosome puff IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcomere IDA
Inferred from Direct Assay
more info
 PubMed 
located_in striated muscle myosin thick filament HDA PubMed 
Preferred Names
myosin heavy chain
Names
CG17927-PA
CG17927-PB
CG17927-PC
CG17927-PD
CG17927-PE
CG17927-PF
CG17927-PG
CG17927-PH
CG17927-PI
CG17927-PK
CG17927-PL
CG17927-PM
CG17927-PN
CG17927-PO
CG17927-PP
CG17927-PQ
CG17927-PR
CG17927-PS
CG17927-PT
CG17927-PU
CG17927-PV
Mhc-PA
Mhc-PB
Mhc-PC
Mhc-PD
Mhc-PE
Mhc-PF
Mhc-PG
Mhc-PH
Mhc-PI
Mhc-PK
Mhc-PL
Mhc-PM
Mhc-PN
Mhc-PO
Mhc-PP
Mhc-PQ
Mhc-PR
Mhc-PS
Mhc-PT
Mhc-PU
Mhc-PV
Not-upheld
Shrunken-thorax
beta-myosin heavy chain
chain
heavy chain
indirect flight muscle (2) RU1
indirect flight muscle (2) RU2
muscle myosin
muscle myosin II
muscle myosin II heavy chain
muscle myosin heavy chain
muscle myosin-II
muscle specific myosin II
myosin
myosin HC
myosin II heavy chain
myosin heavy
myosin heavy Chain-PF
myosin heavy-chain
myosin heavy-chain protein
myosin rod protein
myosin-heavy chain
samba
sarcomeric myosin heavy-chain
shrunken thorax
stuckup
NP_001162990.1
NP_001162991.1
NP_001162992.1
NP_001246048.1
NP_001246049.1
NP_001246050.1
NP_001246051.1
NP_001303327.1
NP_523587.4
NP_723999.1
NP_724000.1
NP_724001.1
NP_724002.2
NP_724003.1
NP_724004.1
NP_724005.1
NP_724006.1
NP_724007.1
NP_724008.1
NP_724009.1
NP_724010.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16766566..16788766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165190.4 → NP_724008.1  myosin heavy chain, isoform K

    See identical proteins and their annotated locations for NP_724008.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A423
    Related
    FBpp0080463
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  2. NM_165181.3 → NP_723999.1  myosin heavy chain, isoform C

    See identical proteins and their annotated locations for NP_723999.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
    Related
    FBpp0080455
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  3. NM_165182.3 → NP_724000.1  myosin heavy chain, isoform G

    See identical proteins and their annotated locations for NP_724000.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
    UniProtKB/TrEMBL
    E1JHJ3
    Related
    FBpp0080452
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  4. NM_165183.3 → NP_724001.1  myosin heavy chain, isoform E

    See identical proteins and their annotated locations for NP_724001.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
    Related
    FBpp0080456
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  5. NM_001259119.2 → NP_001246048.1  myosin heavy chain, isoform R

    See identical proteins and their annotated locations for NP_001246048.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A423, M9NF46
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  6. NM_165185.3 → NP_724003.1  myosin heavy chain, isoform F

    See identical proteins and their annotated locations for NP_724003.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
    Related
    FBpp0080458
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  7. NM_165186.3 → NP_724004.1  myosin heavy chain, isoform D

    See identical proteins and their annotated locations for NP_724004.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A423
    Related
    FBpp0080457
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  8. NM_001169519.2 → NP_001162990.1  myosin heavy chain, isoform N

    See identical proteins and their annotated locations for NP_001162990.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A423, E1JHJ4
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  9. NM_165187.3 → NP_724005.1  myosin heavy chain, isoform A

    See identical proteins and their annotated locations for NP_724005.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A423
    Related
    FBpp0080453
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  10. NM_165188.3 → NP_724006.1  myosin heavy chain, isoform I

    See identical proteins and their annotated locations for NP_724006.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A423
    Related
    FBpp0080460
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  11. NM_078863.6 → NP_523587.4  myosin heavy chain, isoform H

    See identical proteins and their annotated locations for NP_523587.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A423
    Related
    FBpp0080459
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  12. NM_165191.3 → NP_724009.1  myosin heavy chain, isoform L

    See identical proteins and their annotated locations for NP_724009.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A423
    Related
    FBpp0080462
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  13. NM_165192.4 → NP_724010.1  myosin heavy chain, isoform M

    See identical proteins and their annotated locations for NP_724010.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A423
    Related
    FBpp0080464
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  14. NM_001169521.2 → NP_001162992.1  myosin heavy chain, isoform P

    See identical proteins and their annotated locations for NP_001162992.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A423, E1JHJ5
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  15. NM_165189.3 → NP_724007.1  myosin heavy chain, isoform B

    See identical proteins and their annotated locations for NP_724007.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A423
    Related
    FBpp0080454
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  16. NM_001169520.3 → NP_001162991.1  myosin heavy chain, isoform O

    See identical proteins and their annotated locations for NP_001162991.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
    UniProtKB/TrEMBL
    E1JHJ3
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  17. NM_001259122.1 → NP_001246051.1  myosin heavy chain, isoform U

    See identical proteins and their annotated locations for NP_001246051.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A423, M9ND95
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  18. NM_001259120.1 → NP_001246049.1  myosin heavy chain, isoform S

    See identical proteins and their annotated locations for NP_001246049.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
    UniProtKB/TrEMBL
    M9NCU7
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  19. NM_001316398.1 → NP_001303327.1  myosin heavy chain, isoform V

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
    UniProtKB/TrEMBL
    A0A0S0WIH4
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  20. NM_165184.3 → NP_724002.2  myosin heavy chain, isoform Q

    See identical proteins and their annotated locations for NP_724002.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)

  21. NM_001259121.2 → NP_001246050.1  myosin heavy chain, isoform T

    See identical proteins and their annotated locations for NP_001246050.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A423, M9NEP1
    Conserved Domains (7) summary
    cl14654
    Location:1557 → 1877
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00242
    Location:81 → 777
    MYSc; Myosin. Large ATPases
    cd14909
    Location:100 → 765
    MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:842 → 1897
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1739 → 1825
    TMPIT; TMPIT-like protein
    cl21478
    Location:1671 → 1771
    ATP-synt_B; ATP synthase B/B' CF(0)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0S0WIH4 A0A0S0WIH4
E1JHJ3 E1JHJ3
E1JHJ4 E1JHJ4
E1JHJ5 E1JHJ5
M9NCU7 M9NCU7
M9ND95 M9ND95
M9NEP1 M9NEP1
M9NF46 M9NF46
P05661.4 P05661
Q24410 Q24410
Q24411 Q24411
Q26433 Q26433

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