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IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) [ Homo sapiens (human) ]

Gene ID: 3500, updated on 23-Nov-2023

Summary

Official Symbol
IGHG1provided by HGNC
Official Full Name
immunoglobulin heavy constant gamma 1 (G1m marker)provided by HGNC
Primary source
HGNC:HGNC:5525
See related
Ensembl:ENSG00000211896 IMGT/GENE-DB:IGHG1; MIM:147100; AllianceGenome:HGNC:5525
Gene type
other
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Predicted to act upstream of or within several processes, including immunoglobulin mediated immune response; positive regulation of hypersensitivity; and positive regulation of phagocytosis. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See IGHG1 in Genome Data Viewer
Location:
14q32.33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (105741473..105743070, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (100012671..100014268, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (106207810..106209407, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy locus Neighboring gene uncharacterized LOC105378184 Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 1 Neighboring gene immunoglobulin heavy constant epsilon P1 (pseudogene) Neighboring gene immunoglobulin heavy constant alpha 1 Neighboring gene immunoglobulin heavy constant gamma 3 (G3m marker)

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • constant region of heavy chain of IgG1
  • immunoglobulin gamma 1 (Gm marker)

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Fc-gamma receptor I complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables antigen binding TAS
Traceable Author Statement
more info
PubMed 
enables immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in adaptive immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adaptive immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in antibody-dependent cellular cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in complement-dependent cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001019.6 

    Range
    1137275..1138978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    105741473..105743070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187600.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    209242..210839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    100012671..100014268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)