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IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) [ Homo sapiens (human) ]

Gene ID: 3500, updated on 4-Oct-2020

Summary

Official Symbol
IGHG1provided by HGNC
Official Full Name
immunoglobulin heavy constant gamma 1 (G1m marker)provided by HGNC
Primary source
HGNC:HGNC:5525
See related
Ensembl:ENSG00000211896 IMGT/GENE-DB:IGHG1; MIM:147100
Gene type
other
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Genomic context

See IGHG1 in Genome Data Viewer
Location:
14q32.33
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (105741473..105743070, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (106207810..106209407, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987211 Neighboring gene immunoglobulin heavy locus Neighboring gene uncharacterized LOC105378184 Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 1 Neighboring gene immunoglobulin heavy constant epsilon P1 (pseudogene) Neighboring gene immunoglobulin heavy constant gamma 3 (G3m marker)

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • constant region of heavy chain of IgG1
  • immunoglobulin gamma 1 (Gm marker)

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antigen binding TAS
Traceable Author Statement
more info
PubMed 
immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
complement activation TAS
Traceable Author Statement
more info
 
complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
complement activation, classical pathway TAS
Traceable Author Statement
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytosis, recognition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of complement activation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
immunoglobulin complex, circulating IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001019.6 

    Range
    1137275..1138978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    105741473..105743070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187600.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    209242..210839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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