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IGHE immunoglobulin heavy constant epsilon [ Homo sapiens (human) ]

Gene ID: 3497, updated on 8-Dec-2022

Summary

Official Symbol
IGHEprovided by HGNC
Official Full Name
immunoglobulin heavy constant epsilonprovided by HGNC
Primary source
HGNC:HGNC:5522
See related
Ensembl:ENSG00000211891 IMGT/GENE-DB:IGHE; MIM:147180; AllianceGenome:HGNC:5522
Gene type
other
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IgE
Summary
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Predicted to be located in extracellular region. Predicted to be part of immunoglobulin complex, circulating. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See IGHE in Genome Data Viewer
Location:
14q32.33
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (105600066..105601727, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (99852516..99854177, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (106066403..106068064, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370698 Neighboring gene ETS transcription factor ELK2B, pseudogene Neighboring gene microRNA 8071-1 Neighboring gene immunoglobulin heavy constant alpha 2 (A2m marker) Neighboring gene immunoglobulin heavy locus Neighboring gene immunoglobulin heavy constant gamma 4 (G4m marker)

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • constant region of heavy chain of IgE
  • immunoglobulin epsilon

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in adaptive immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in immune response NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of IgE immunoglobulin complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space NAS
Non-traceable Author Statement
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001019.6 

    Range
    1278618..1280403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    105600066..105601727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187600.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    67840..69501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    99852516..99854177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)