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PLET1 placenta expressed transcript 1 [ Homo sapiens (human) ]

Gene ID: 349633, updated on 5-Jul-2025
Official Symbol
PLET1provided by HGNC
Official Full Name
placenta expressed transcript 1provided by HGNC
Primary source
HGNC:HGNC:30053
See related
Ensembl:ENSG00000188771 MIM:611904; AllianceGenome:HGNC:30053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C11orf34
Summary
Predicted to be involved in negative regulation of cell-matrix adhesion; positive regulation of cell migration; and wound healing, spreading of epidermal cells. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in apical plasma membrane and external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
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See PLET1 in Genome Data Viewer
Location:
11q23.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (112248153..112260860, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (112258488..112271159, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (112118876..112131583, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3906 Neighboring gene Sharpr-MPRA regulatory region 3969 Neighboring gene 6-pyruvoyltetrahydropterin synthase Neighboring gene ribosomal protein S6 pseudogene 16 Neighboring gene uncharacterized LOC100132686 Neighboring gene long intergenic non-protein coding RNA 2762 Neighboring gene ST13, Hsp70 interacting protein pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5533 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:112160899-112161647 Neighboring gene NANOG hESC enhancer GRCh37_chr11:112178337-112178838 Neighboring gene uncharacterized LOC107984388

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cell-matrix adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in wound healing, spreading of epidermal cells IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in wound healing, spreading of epidermal cells ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
placenta-expressed transcript 1 protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145024.1NP_001138496.1  placenta-expressed transcript 1 protein precursor

    See identical proteins and their annotated locations for NP_001138496.1

    Status: VALIDATED

    Source sequence(s)
    AP002884, AY364431, AY364435
    Consensus CDS
    CCDS44732.1
    UniProtKB/Swiss-Prot
    Q6UQ24, Q6UQ25, Q6UQ27, Q6UQ28
    Related
    ENSP00000341412.2, ENST00000338832.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    112248153..112260860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    112258488..112271159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)