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IGHA2 immunoglobulin heavy constant alpha 2 (A2m marker) [ Homo sapiens (human) ]

Gene ID: 3494, updated on 5-Jan-2022

Summary

Official Symbol
IGHA2provided by HGNC
Official Full Name
immunoglobulin heavy constant alpha 2 (A2m marker)provided by HGNC
Primary source
HGNC:HGNC:5479
See related
Ensembl:ENSG00000211890 IMGT/GENE-DB:IGHA2; MIM:147000
Gene type
other
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A2M
Summary
Contributes to immunoglobulin receptor binding activity. Involved in antibacterial humoral response; glomerular filtration; and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Nov 2021]
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Genomic context

See IGHA2 in Genome Data Viewer
Location:
14q32.33
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (105586937..105588394, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (106053274..106054731, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370698 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 1 Neighboring gene ETS transcription factor ELK2B, pseudogene Neighboring gene microRNA 8071-1 Neighboring gene immunoglobulin heavy constant epsilon Neighboring gene immunoglobulin heavy locus

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • constant region of heavy chain of IgA2
  • immunoglobulin alpha 2 (A2M marker)

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables antigen binding TAS
Traceable Author Statement
more info
PubMed 
contributes_to immunoglobulin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in antibacterial humoral response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glomerular filtration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis, recognition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of respiratory burst IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retina homeostasis HEP PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001019.6 

    Range
    1291951..1293438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    105586937..105588394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187600.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    55293..56750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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