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IGFBP4 insulin like growth factor binding protein 4 [ Homo sapiens (human) ]

Gene ID: 3487, updated on 7-Dec-2018

Summary

Official Symbol
IGFBP4provided by HGNC
Official Full Name
insulin like growth factor binding protein 4provided by HGNC
Primary source
HGNC:HGNC:5473
See related
Ensembl:ENSG00000141753 MIM:146733
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BP-4; IBP4; IGFBP-4; HT29-IGFBP
Summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in liver (RPKM 316.3), ovary (RPKM 298.9) and 21 other tissues See more
Orthologs

Genomic context

See IGFBP4 in Genome Data Viewer
Location:
17q21.2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (40443424..40457730)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38599676..38613982)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase II alpha Neighboring gene ribosomal protein L23a pseudogene 75 Neighboring gene uncharacterized LOC107985064 Neighboring gene tensin 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Using a yeast two-hybrid system, HIV-1 Tat has been shown to bind the human insulin-like growth factor binding protein 4, suggesting a role for this protein in mediating the biological activity of Tat during HIV-1 replication PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA metabolic process TAS
Traceable Author Statement
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor-binding protein 4
Names
IBP-4
IGF-binding protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001552.3NP_001543.2  insulin-like growth factor-binding protein 4 precursor

    See identical proteins and their annotated locations for NP_001543.2

    Status: REVIEWED

    Source sequence(s)
    AC018629, BC016041, CN431519
    Consensus CDS
    CCDS11367.1
    UniProtKB/Swiss-Prot
    P22692
    UniProtKB/TrEMBL
    A0A024R1U8
    Related
    ENSP00000269593.4, ENST00000269593.4
    Conserved Domains (2) summary
    smart00121
    Location:25101
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:174249
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    40443424..40457730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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