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osp outspread [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34850, updated on 9-Dec-2024

Summary

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Official Symbol
ospprovided by FlyBase
Official Full Name
outspreadprovided by FlyBase
Primary source
FLYBASE:FBgn0003016
Locus tag
Dmel_CG3479
See related
AllianceGenome:FB:FBgn0003016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
alw; anon-WO02059370.75; BG:DS01486.5; BG:DS01486.7; BG:DS07721.2; CG3479; Dmel\CG3479; l(2)rJ571; v(2)rJ571
Summary
Predicted to enable actin filament binding activity. Predicted to be active in actin cytoskeleton. Is expressed in embryonic foregut; embryonic hypopharynx; gland; salivary gland body primordium; and spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 28. Orthologous to several human genes including MPRIP (myosin phosphatase Rho interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See osp in Genome Data Viewer
Location:
35B3-35B4; 2-50 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14599196..14689340, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14599196..14689340, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene transfer RNA:Proline-AGG 1-2 Neighboring gene transfer RNA:Proline-AGG 1-3 Neighboring gene transfer RNA:Proline-AGG 1-4 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43411 Neighboring gene Adh-related Neighboring gene Alcohol dehydrogenase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Demonstration of in vivo engineered tandem duplications of varying sizes using CRISPR and recombinases in Drosophila melanogaster. Loehlin DW, et al. G3 (Bethesda), 2023 Sep 30. PMID 37462278, Free PMC Article
  2. FB elements can promote exon shuffling: a promoter-less white allele can be reactivated by FB mediated transposition in Drosophila melanogaster. Moschetti R, et al. Mol Genet Genomics, 2004 May. PMID 15060822
  3. The alcohol dehydrogenase gene is nested in the outspread locus of Drosophila melanogaster. McNabb S, et al. Genetics, 1996 Jun. PMID 8725237, Free PMC Article
  4. Analysis of ENU-induced mutations at the Adh locus in Drosophila melanogaster. Fossett NG, et al. Mutat Res, 1990 Jul. PMID 2114535
  5. Molecular analysis of the Adh region of the genome of Drosophila melanogaster. Chia W, et al. J Mol Biol, 1985 Dec 20. PMID 3005593

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

mobile_element

  • Loc: c14619298-14618937 mobile_element_type = transposon:jockey{}370
  • Loc: c14651730-14642626 mobile_element_type = transposon:roo{}371

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
outspread
Names
CG3479-PC
CG3479-PD
CG3479-PE
CG3479-PF
arc-like wing
arclike wing
osp-PC
osp-PD
osp-PE
osp-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    14599196..14689340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169504.2 → NP_001162975.1  outspread, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162975.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2VEG2, A9UN92, B7YZW1, E1JHH8, Q24231, Q27421, Q7KT89, Q8MSX4, Q9VJS4
    Conserved Domains (4) summary
    COG0419
    Location:726 → 1353
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01236
    Location:48 → 191
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:509 → 613
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:509 → 603
    PH; PH domain

  2. NM_078843.6 → NP_523567.5  outspread, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523567.5

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27421
    Conserved Domains (4) summary
    COG0419
    Location:717 → 1344
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01236
    Location:48 → 182
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:500 → 604
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:500 → 594
    PH; PH domain

  3. NM_165089.4 → NP_723879.3  outspread, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723879.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27421
    Conserved Domains (4) summary
    COG0419
    Location:717 → 1344
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01236
    Location:48 → 182
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:500 → 604
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:500 → 594
    PH; PH domain

  4. NM_001144354.3 → NP_001137826.1  outspread, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137826.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27421
    Conserved Domains (4) summary
    COG0419
    Location:726 → 1353
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01236
    Location:48 → 191
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:509 → 613
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:509 → 603
    PH; PH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27421.5 Q27421

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