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IGFBP2 insulin like growth factor binding protein 2 [ Homo sapiens (human) ]

Gene ID: 3485, updated on 8-Dec-2018

Summary

Official Symbol
IGFBP2provided by HGNC
Official Full Name
insulin like growth factor binding protein 2provided by HGNC
Primary source
HGNC:HGNC:5471
See related
Ensembl:ENSG00000115457 MIM:146731
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IBP2; IGF-BP53
Summary
The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Broad expression in liver (RPKM 67.6), stomach (RPKM 67.2) and 20 other tissues See more
Orthologs

Genomic context

See IGFBP2 in Genome Data Viewer
Location:
2q35
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (216632828..216664436)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217498127..217529159)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1280 Neighboring gene proteasome subunit beta 3 pseudogene 2 Neighboring gene uncharacterized LOC101928278 Neighboring gene insulin like growth factor binding protein 5 Neighboring gene ribosomal protein L31 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu The gene expression of insulin-like growth factor binding protein 2 (IGFBP2) increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates IGFBP2 protein expression PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor I binding IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor II binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of activated T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of insulin-like growth factor receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
regulation of insulin-like growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to estrogen IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to lithium ion IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor-binding protein 2
Names
IGF-binding protein 2
insulin-like growth factor binding protein 2, 36kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000597.3NP_000588.3  insulin-like growth factor-binding protein 2 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC071967, M35410
    Consensus CDS
    CCDS42815.1
    Related
    ENSP00000233809.4, ENST00000233809.8
    Conserved Domains (2) summary
    smart00121
    Location:40132
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:227306
    Thyroglobulin_1; Thyroglobulin type-1 repeat
  2. NM_001313990.1NP_001300919.1  insulin-like growth factor-binding protein 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC007563, BC004312, BE735562
    Consensus CDS
    CCDS82570.1
    UniProtKB/Swiss-Prot
    P18065
    UniProtKB/TrEMBL
    C9JMY1
    Related
    ENSP00000389646.1, ENST00000456764.1
    Conserved Domains (1) summary
    pfam00086
    Location:83162
    Thyroglobulin_1; Thyroglobulin type-1 repeat
  3. NM_001313992.1NP_001300921.1  insulin-like growth factor-binding protein 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    BC004312, CV810939
    UniProtKB/Swiss-Prot
    P18065
    Conserved Domains (1) summary
    pfam00086
    Location:61140
    Thyroglobulin_1; Thyroglobulin type-1 repeat
  4. NM_001313993.1NP_001300922.1  insulin-like growth factor-binding protein 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AC073321, BC004312, CN431340
    UniProtKB/Swiss-Prot
    P18065
    Conserved Domains (1) summary
    pfam00086
    Location:61140
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    216632828..216664436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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