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spel1 spellchecker1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34842, updated on 10-Jan-2019

Summary

Official Symbol
spel1provided by FlyBase
Official Full Name
spellchecker1provided by FlyBase
Primary source
FLYBASE:FBgn0015546
Locus tag
Dmel_CG4215
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS01068.9; CG4215; Dmel\CG4215; Msh2; spel; spel-1; SPEL1

Genomic context

See spel1 in Genome Data Viewer
Location:
35A4-35B1; 2-50 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.18 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14362069..14366840)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14362069..14366840)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Rab14 Neighboring gene Polypeptide N-acetylgalactosaminyltransferase 35A Neighboring gene ncRNA Neighboring gene pickpocket Neighboring gene elbow B

Genomic regions, transcripts, and products

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the spel1 gene: The spel1 gene is conserved in human, dog, cow, mouse, rat, chicken, zebrafish, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.
  • Orthologs

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
DNA-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to guanine/thymine mispair binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single thymine insertion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interstrand cross-link repair IGI
Inferred from Genetic Interaction
more info
PubMed 
interstrand cross-link repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
intra-S DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maintenance of DNA repeat elements IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maintenance of DNA repeat elements IMP
Inferred from Mutant Phenotype
more info
PubMed 
mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postreplication repair ISS
Inferred from Sequence or Structural Similarity
more info
 
response to UV-B IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to X-ray IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
MutSalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MutSbeta complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
spellchecker1
Names
CG4215-PA
CG4215-PD
CG4215-PE
CG4215-PF
spel1-PA
spel1-PD
spel1-PE
spel1-PF
spellchecker
spellchecker 1
NP_001014482.2
NP_001246031.1
NP_001285931.1
NP_523565.2

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    14362069..14366840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259102.2NP_001246031.1  spellchecker1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246031.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P43248
    UniProtKB/TrEMBL
    M9ND86
    Related
    FBpp0301208, FBtr0309281
    Conserved Domains (6) summary
    smart00533
    Location:324643
    MUTSd; DNA-binding domain of DNA mismatch repair MUTS family
    pfam00488
    Location:617852
    MutS_V; MutS domain V
    pfam01624
    Location:24132
    MutS_I; MutS domain I
    pfam05188
    Location:149287
    MutS_II; MutS domain II
    pfam05190
    Location:471567
    MutS_IV; MutS family domain IV
    pfam05192
    Location:326414
    MutS_III; MutS domain III
  2. NM_001299002.1NP_001285931.1  spellchecker1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285931.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P43248
    UniProtKB/TrEMBL
    M9ND86
    Related
    FBpp0310470, FBtr0344019
    Conserved Domains (6) summary
    smart00533
    Location:324643
    MUTSd; DNA-binding domain of DNA mismatch repair MUTS family
    pfam00488
    Location:617852
    MutS_V; MutS domain V
    pfam01624
    Location:24132
    MutS_I; MutS domain I
    pfam05188
    Location:149287
    MutS_II; MutS domain II
    pfam05190
    Location:471567
    MutS_IV; MutS family domain IV
    pfam05192
    Location:326414
    MutS_III; MutS domain III
  3. NM_001014482.3NP_001014482.2  spellchecker1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014482.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P43248
    UniProtKB/TrEMBL
    M9ND86
    Related
    FBpp0310469, FBtr0344018
    Conserved Domains (6) summary
    smart00533
    Location:324643
    MUTSd; DNA-binding domain of DNA mismatch repair MUTS family
    pfam00488
    Location:617852
    MutS_V; MutS domain V
    pfam01624
    Location:24132
    MutS_I; MutS domain I
    pfam05188
    Location:149287
    MutS_II; MutS domain II
    pfam05190
    Location:471567
    MutS_IV; MutS family domain IV
    pfam05192
    Location:326414
    MutS_III; MutS domain III
  4. NM_078841.5NP_523565.2  spellchecker1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523565.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P43248
    UniProtKB/TrEMBL
    M9ND86
    Related
    FBpp0080203, FBtr0080630
    Conserved Domains (6) summary
    smart00533
    Location:324643
    MUTSd; DNA-binding domain of DNA mismatch repair MUTS family
    pfam00488
    Location:617852
    MutS_V; MutS domain V
    pfam01624
    Location:24132
    MutS_I; MutS domain I
    pfam05188
    Location:149287
    MutS_II; MutS domain II
    pfam05190
    Location:471567
    MutS_IV; MutS family domain IV
    pfam05192
    Location:326414
    MutS_III; MutS domain III
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