Rab14 Rab14 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab14provided by FlyBase
Official Full Name: Rab14provided by FlyBase
Primary source: FLYBASE:FBgn0015791
Locus tag: Dmel_CG4212
See related: AllianceGenome:FB:FBgn0015791
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 57H4T; AAF53390; anon-sts33; BG:DS01068.7; CG4212; Dmel\CG4212; DmRab14; DRab14; DRAB14; ESTS:57H4T; O18336; Rab-r14; rab14
Summary: Predicted to enable GTPase activity. Involved in phagolysosome assembly. Located in endosome; neuronal cell body; and synapse. Is expressed in several structures, including brain; glial cell; imaginal disc; mushroom body; and synaptic neuropil domain. Orthologous to human RAB14 (RAB14, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (14355145..14358764)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (14355145..14358764)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Golgi to endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to endosome transport	IEA Inferred from Electronic Annotation more info
involved_in Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in endocytic recycling	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagolysosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagolysosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagosome maturation	IEA Inferred from Electronic Annotation more info
involved_in phagosome maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	HMP more info	PubMed
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	HDA more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	HDA more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in phagocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info