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SELENOV selenoprotein V [ Homo sapiens (human) ]

Gene ID: 348303, updated on 1-Jun-2020

Summary

Official Symbol
SELENOVprovided by HGNC
Official Full Name
selenoprotein Vprovided by HGNC
Primary source
HGNC:HGNC:30399
See related
Ensembl:ENSG00000186838 MIM:607919
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SELV
Summary
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2017]
Expression
Restricted expression toward testis (RPKM 2.7) See more
Orthologs

Genomic context

See SELENOV in Genome Data Viewer
Location:
19q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (39515113..39520686)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40005753..40011326)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 50 Neighboring gene delta like canonical Notch ligand 3 Neighboring gene EP300 interacting inhibitor of differentiation 2B Neighboring gene teratocarcinoma-derived growth factor 1 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
response to selenium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001350809.1NP_001337738.1  selenoprotein V isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon compared to variant 1. The resulting shorter isoform (2) lacks an internal protein segment compared to isoform 1.
    Source sequence(s)
    AY324825, HY191948
    Conserved Domains (1) summary
    cl01407
    Location:265302
    Rdx; Rdx family
  2. NM_182704.1NP_874363.1  selenoprotein V isoform 1

    See identical proteins and their annotated locations for NP_874363.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AY324825
    Consensus CDS
    CCDS54266.1
    UniProtKB/Swiss-Prot
    P59797
    Related
    ENSP00000333956.4, ENST00000335426.8
    Conserved Domains (1) summary
    TIGR02174
    Location:265336
    CXXU_selWTH; selT/selW/selH selenoprotein domain

RNA

  1. NR_146916.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two non-consecutive exons compared to variant 1. It is represented as non-coding because the use of the 5'-most translation start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY324825, HY191948

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    39515113..39520686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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