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MCRIP1 MAPK regulated corepressor interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 348262, updated on 1-Jun-2020

Summary

Official Symbol
MCRIP1provided by HGNC
Official Full Name
MAPK regulated corepressor interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:28007
See related
Ensembl:ENSG00000225663 MIM:616514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRAN2; MCRIP; FAM195B
Expression
Ubiquitous expression in testis (RPKM 31.8), fat (RPKM 25.2) and 25 other tissues See more
Orthologs

Genomic context

See MCRIP1 in Genome Data Viewer
Location:
17q25.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81822361..81833291, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79780293..79791167, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376789 Neighboring gene glucagon receptor Neighboring gene Sharpr-MPRA regulatory region 4607 Neighboring gene protein phosphatase 1 regulatory subunit 27 Neighboring gene prolyl 4-hydroxylase subunit beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133184, DKFZp686A17165

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mapk-regulated corepressor-interacting protein 1
Names
MAPK-regulated co-repressor interacting protein 1
MCRIP1 protein
family with sequence similarity 195, member B
granulin-2
protein FAM195B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093767.3NP_001087236.1  mapk-regulated corepressor-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001087236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    BE831904, BX649156
    Consensus CDS
    CCDS45814.1
    UniProtKB/Swiss-Prot
    C9JLW8
    UniProtKB/TrEMBL
    A0A024R8R5
    Related
    ENSP00000445543.1, ENST00000538396.5
    Conserved Domains (1) summary
    pfam14799
    Location:489
    FAM195; FAM195 family
  2. NM_001288798.2NP_001275727.1  mapk-regulated corepressor-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001275727.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (1).
    Source sequence(s)
    BC094876, BE831904, BG830426
    Consensus CDS
    CCDS74179.1
    UniProtKB/TrEMBL
    I3L4Q0
    Related
    ENSP00000461433.1, ENST00000572645.5
    Conserved Domains (1) summary
    pfam14799
    Location:25110
    FAM195; FAM195 family
  3. NM_001288799.2NP_001275728.1  mapk-regulated corepressor-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001275728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, resulting in different UTRs and translation initiation at a downstream start codon, compared to variant 3. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    BC063557, BE831904, BG830426, BU188846
    Consensus CDS
    CCDS74178.1
    UniProtKB/TrEMBL
    I3L3A7
    Related
    ENSP00000460299.1, ENST00000573478.5
    Conserved Domains (1) summary
    pfam14799
    Location:443
    FAM195; FAM195 family
  4. NM_207368.5NP_997251.2  mapk-regulated corepressor-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_997251.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the UTRs, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK000852, BC094876, BE831904, BG830426
    Consensus CDS
    CCDS45814.1
    UniProtKB/Swiss-Prot
    C9JLW8
    UniProtKB/TrEMBL
    A0A024R8R5
    Related
    ENSP00000409009.2, ENST00000455127.7
    Conserved Domains (1) summary
    pfam14799
    Location:489
    FAM195; FAM195 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    81822361..81833291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523571.2XP_011521873.1  mapk-regulated corepressor-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011521873.1

    UniProtKB/TrEMBL
    I3L4Q0
    Conserved Domains (1) summary
    pfam14799
    Location:25110
    FAM195; FAM195 family
  2. XM_011523572.2XP_011521874.1  mapk-regulated corepressor-interacting protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011521874.1

    Conserved Domains (1) summary
    pfam14799
    Location:2580
    FAM195; FAM195 family

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160021.1 Reference GRCh38.p13 PATCHES

    Range
    35854..46784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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