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SKA2 spindle and kinetochore associated complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 348235, updated on 7-Jun-2020

Summary

Official Symbol
SKA2provided by HGNC
Official Full Name
spindle and kinetochore associated complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:28006
See related
Ensembl:ENSG00000182628 MIM:616674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM33A
Expression
Ubiquitous expression in brain (RPKM 9.5), thyroid (RPKM 8.8) and 25 other tissues See more
Orthologs

Genomic context

See SKA2 in Genome Data Viewer
Location:
17q22
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (59109857..59155186, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (57187308..57232800, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1E Neighboring gene ribosomal protein S12 pseudogene 30 Neighboring gene tripartite motif containing 37 Neighboring gene RNA, 7SL, cytoplasmic 716, pseudogene Neighboring gene RNA, U2 small nuclear 58, pseudogene Neighboring gene microRNA 454 Neighboring gene microRNA 301a Neighboring gene speedy/RINGO cell cycle regulator family member E22, pseudogene Neighboring gene proline rich 11 Neighboring gene SMG8 nonsense mediated mRNA decay factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12758, MGC110975

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of microtubule polymerization or depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
condensed chromosome outer kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
condensed chromosome outer kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
spindle and kinetochore-associated protein 2
Names
family with sequence similarity 33, member A
spindle and KT (kinetochore) associated 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100595.2NP_001094065.1  spindle and kinetochore-associated protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. The biological validity of the predicted protein sequence needs to be experimentally verified.
    Source sequence(s)
    AC099850, BQ019350, DA133216, DB158057
    Consensus CDS
    CCDS45748.1
    UniProtKB/Swiss-Prot
    Q8WVK7
    Related
    ENSP00000411231.2, ENST00000437036.6
  2. NM_001330399.2NP_001317328.1  spindle and kinetochore-associated protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC099850, AK022820, DA020580, DB158057
    Consensus CDS
    CCDS82175.1
    UniProtKB/TrEMBL
    J3KSP0
    Related
    ENSP00000462574.1, ENST00000583380.5
    Conserved Domains (1) summary
    cd12955
    Location:5100
    SKA2; Spindle and kinetochore-associated protein 2
  3. NM_182620.4NP_872426.1  spindle and kinetochore-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_872426.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC099850, BC106003, BQ019350, DB158057
    Consensus CDS
    CCDS45747.1
    UniProtKB/Swiss-Prot
    Q8WVK7
    Related
    ENSP00000333433.7, ENST00000330137.12
    Conserved Domains (1) summary
    cd12955
    Location:5120
    SKA2; Spindle and kinetochore-associated protein 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    59109857..59155186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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