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CLEC18A C-type lectin domain family 18 member A [ Homo sapiens (human) ]

Gene ID: 348174, updated on 16-Aug-2021

Summary

Official Symbol
CLEC18Aprovided by HGNC
Official Full Name
C-type lectin domain family 18 member Aprovided by HGNC
Primary source
HGNC:HGNC:30388
See related
Ensembl:ENSG00000157322 MIM:616571
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRCL; MRCL1; MRLP2
Summary
This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion, immune response and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]
Expression
Biased expression in kidney (RPKM 14.8), testis (RPKM 4.0) and 1 other tissue See more
Orthologs
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Genomic context

See CLEC18A in Genome Data Viewer
Location:
16q22.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (69950232..69968478)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69984608..69997889)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene non-POU domain containing, octamer-binding pseudogene 1 Neighboring gene WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene microRNA 140 Neighboring gene nuclear pore complex-interacting protein Neighboring gene nuclear pore complex interacting protein family member B14, pseudogene Neighboring gene pyridoxal dependent decarboxylase domain containing 2, pseudogene Neighboring gene microRNA 1972-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ77955, MGC164804

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables polysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables polysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
located_in endosome TAS
Traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
C-type lectin domain family 18 member A
Names
mannose receptor-like 1
mannose receptor-like protein 2
mannose receptor-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136214.4NP_001129686.1  C-type lectin domain family 18 member A precursor

    See identical proteins and their annotated locations for NP_001129686.1

    Status: REVIEWED

    Source sequence(s)
    AC026468
    Consensus CDS
    CCDS10886.1
    UniProtKB/Swiss-Prot
    A5D8T8
    Related
    ENSP00000484176.1, ENST00000615430.4
    Conserved Domains (2) summary
    cd00037
    Location:310434
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd05380
    Location:50183
    CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins
  2. NM_001271197.3NP_001258126.1  C-type lectin domain family 18 member A precursor

    See identical proteins and their annotated locations for NP_001258126.1

    Status: REVIEWED

    Source sequence(s)
    AC026468
    Consensus CDS
    CCDS10886.1
    UniProtKB/Swiss-Prot
    A5D8T8
    Related
    ENSP00000454685.1, ENST00000568461.5
    Conserved Domains (2) summary
    cd00037
    Location:310434
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd05380
    Location:50183
    CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins
  3. NM_001370523.4NP_001357452.1  C-type lectin domain family 18 member A precursor

    Status: REVIEWED

    Source sequence(s)
    AC026468
    Related
    ENSP00000288040.6, ENST00000288040.10
    Conserved Domains (2) summary
    cd00037
    Location:310434
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd05380
    Location:50183
    CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins
  4. NM_182619.5NP_872425.2  C-type lectin domain family 18 member A precursor

    See identical proteins and their annotated locations for NP_872425.2

    Status: REVIEWED

    Source sequence(s)
    AC026468
    Consensus CDS
    CCDS10886.1
    UniProtKB/Swiss-Prot
    A5D8T8
    Related
    ENSP00000377304.2, ENST00000393701.6
    Conserved Domains (2) summary
    cd00037
    Location:310434
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd05380
    Location:50183
    CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    69950232..69968478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023208.2XP_016878697.1  C-type lectin domain family 18 member A isoform X3

  2. XM_017023207.1XP_016878696.1  C-type lectin domain family 18 member A isoform X3

  3. XM_017023206.1XP_016878695.1  C-type lectin domain family 18 member A isoform X1

RNA

  1. XR_001751900.1 RNA Sequence

  2. XR_002957800.1 RNA Sequence

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