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NimC1 Nimrod C1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34816, updated on 15-May-2025
Official Symbol
NimC1provided by FlyBase
Official Full Name
Nimrod C1provided by FlyBase
Primary source
FLYBASE:FBgn0259896
Locus tag
Dmel_CG8942
See related
AllianceGenome:FB:FBgn0259896
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS00180.10; CG8942; CT25688; Dmel\CG8942; Nim; NimC; nimC1; nimrod; nimrod C1; P1
Summary
Involved in defense response to bacterium and phagocytosis. Located in plasma membrane. Is expressed in adult head; cortical zone of lymph gland primary lobe; embryonic/larval lymph gland; embryonic/larval plasmatocyte; and hemocyte. [provided by Alliance of Genome Resources, May 2025]
Orthologs
all
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See NimC1 in Genome Data Viewer
Location:
34E5-34E5; 2-50 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13973158..13976769, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13973158..13976769, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Nimrod B4 Neighboring gene Nimrod B5 Neighboring gene Hemese Neighboring gene Cytochrome P450 28a5 Neighboring gene Nimrod C2 Neighboring gene rickets

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Edin Expression in the Fat Body Is Required in the Defense Against Parasitic Wasps in Drosophila melanogaster. Vanha-Aho LM, et al. PLoS Pathog, 2015 May. PMID 25965263, Free PMC Article
  2. Widely Used Mutants of eiger, Encoding the Drosophila Tumor Necrosis Factor, Carry Additional Mutations in the NimrodC1 Phagocytosis Receptor. Kodra A, et al. G3 (Bethesda), 2020 Dec 3. PMID 33127847, Free PMC Article
  3. Variation of NimC1 expression in Drosophila stocks and transgenic strains. Honti V, et al. Fly (Austin), 2013 Oct-Dec. PMID 23899817, Free PMC Article
  4. Methods and tools for spatial mapping of single-cell RNAseq clusters in Drosophila. Mohr SE, et al. Genetics, 2021 Apr 15. PMID 33713129, Free PMC Article
  5. Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster. Márkus R, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19261847, Free PMC Article

See all (125) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
nimrod C1
Names
CG8942-PA
CG8942-PB
CG8942-PC
NimC1-PA
NimC1-PB
NimC1-PC
NimrodC1
nimrod

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13973158..13976769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298992.1 → NP_001285921.1  nimrod C1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285921.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H5V8G7, M9PBB4
    Conserved Domains (1) summary
    pfam09402
    Location:244 → 281
    MSC; Man1-Src1p-C-terminal domain

  2. NM_135849.4 → NP_609693.1  nimrod C1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609693.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H5V8G7, Q9NKD8, Q9VJU5
    Related
    FBpp0080188
    Conserved Domains (2) summary
    pfam07546
    Location:25 → 89
    EMI; EMI domain
    pfam09402
    Location:242 → 279
    MSC; Man1-Src1p-C-terminal domain

  3. NM_001273524.1 → NP_001260453.1  nimrod C1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260453.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H5V8G7, M9PBB4
    Conserved Domains (1) summary
    pfam09402
    Location:244 → 281
    MSC; Man1-Src1p-C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBB4 M9PBB4
Q8MS81 Q8MS81
Q9VJU5 Q9VJU5

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