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RBPMS2 RNA binding protein, mRNA processing factor 2 [ Homo sapiens (human) ]

Gene ID: 348093, updated on 7-Jun-2020

Summary

Official Symbol
RBPMS2provided by HGNC
Official Full Name
RNA binding protein, mRNA processing factor 2provided by HGNC
Primary source
HGNC:HGNC:19098
See related
Ensembl:ENSG00000166831
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the RNA recognition motif (RRM)-containing protein family and is involved in the development and dedifferentiation of digestive smooth muscle cells. The encoded protein functions as a homodimer and indirectly inhibits the bone morphogenetic protein pathway. [provided by RefSeq, Aug 2016]
Expression
Biased expression in heart (RPKM 68.7), urinary bladder (RPKM 14.2) and 8 other tissues See more
Orthologs

Genomic context

See RBPMS2 in Genome Data Viewer
Location:
15q22.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (64739891..64775589, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65032093..65067770, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase antizyme 2 Neighboring gene uncharacterized LOC107984737 Neighboring gene microRNA 1272 Neighboring gene PIF1 5'-to-3' DNA helicase Neighboring gene pleckstrin homology domain containing O2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
embryonic digestive tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of smooth muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of smooth muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein with multiple splicing 2
Names
RNA binding protein with multiple splicing 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194272.3NP_919248.1  RNA-binding protein with multiple splicing 2

    See identical proteins and their annotated locations for NP_919248.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC091582, AI274305, AK127873
    Consensus CDS
    CCDS32271.1
    UniProtKB/Swiss-Prot
    Q6ZRY4
    Related
    ENSP00000300069.4, ENST00000300069.5
    Conserved Domains (1) summary
    cd12683
    Location:30105
    RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

RNA

  1. NR_138350.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC091582, AI274305, AK127873, DA564899
  2. NR_138363.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AI274305, AK127873, DA565836
  3. NR_138364.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC100830, AI274305, AK124123
    Related
    ENST00000560606.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    64739891..64775589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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