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TMEM255B transmembrane protein 255B [ Homo sapiens (human) ]

Gene ID: 348013, updated on 25-Jan-2022

Summary

Official Symbol
TMEM255Bprovided by HGNC
Official Full Name
transmembrane protein 255Bprovided by HGNC
Primary source
HGNC:HGNC:28297
See related
Ensembl:ENSG00000184497 AllianceGenome:HGNC:28297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM70B
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in lung (RPKM 1.8), gall bladder (RPKM 1.7) and 24 other tissues See more
Orthologs
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Genomic context

See TMEM255B in Genome Data Viewer
Location:
13q34
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (113759217..113816995)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114462199..114519968)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 1 Neighboring gene ATPase H+/K+ transporting subunit beta Neighboring gene basic salivary proline-rich protein 4-like Neighboring gene long intergenic non-protein coding RNA 552 Neighboring gene GAS6 antisense RNA 1 Neighboring gene growth arrest specific 6 Neighboring gene GAS6 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ57938, MGC20579

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 255B
Names
family with sequence similarity 70, member B
protein FAM70B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348663.2NP_001335592.1  transmembrane protein 255B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC187648, BX072579, BX088578
    Conserved Domains (1) summary
    pfam14967
    Location:5277
    FAM70; FAM70 protein
  2. NM_182614.4NP_872420.1  transmembrane protein 255B isoform 1

    See identical proteins and their annotated locations for NP_872420.1

    Status: VALIDATED

    Source sequence(s)
    AC187648, BC018995, BX072579
    Consensus CDS
    CCDS45071.1
    UniProtKB/Swiss-Prot
    Q8WV15
    Related
    ENSP00000364502.3, ENST00000375353.5
    Conserved Domains (1) summary
    pfam14967
    Location:5325
    FAM70; FAM70 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    113759217..113816995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020558.1XP_016876047.1  transmembrane protein 255B isoform X1

  2. XM_005272413.3XP_005272470.1  transmembrane protein 255B isoform X2

    Conserved Domains (2) summary
    pfam13273
    Location:28101
    DUF4064; Protein of unknown function (DUF4064)
    pfam14967
    Location:5356
    FAM70; FAM70 protein
  3. XM_017020560.1XP_016876049.1  transmembrane protein 255B isoform X4

  4. XM_005272415.3XP_005272472.1  transmembrane protein 255B isoform X5

    See identical proteins and their annotated locations for XP_005272472.1

    Conserved Domains (1) summary
    pfam14967
    Location:49236
    FAM70; FAM70 protein
  5. XM_024449345.1XP_024305113.1  transmembrane protein 255B isoform X6

    Conserved Domains (1) summary
    pfam14967
    Location:39222
    FAM70; FAM70 protein
  6. XM_017020559.1XP_016876048.1  transmembrane protein 255B isoform X3

  7. XM_006719986.2XP_006720049.1  transmembrane protein 255B isoform X5

    See identical proteins and their annotated locations for XP_006720049.1

    Conserved Domains (1) summary
    pfam14967
    Location:49236
    FAM70; FAM70 protein
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