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GATD1 glutamine amidotransferase class 1 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 347862, updated on 4-Nov-2022

Summary

Official Symbol
GATD1provided by HGNC
Official Full Name
glutamine amidotransferase class 1 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:26616
See related
Ensembl:ENSG00000177225 AllianceGenome:HGNC:26616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDDC1
Summary
Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 7.5), brain (RPKM 7.2) and 25 other tissues See more
Orthologs
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Genomic context

See GATD1 in Genome Data Viewer
Location:
11p15.5
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (767222..777487, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (818734..828922, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (767222..777487, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376509 Neighboring gene transaldolase 1 Neighboring gene uncharacterized LOC124900301 Neighboring gene GATD1 divergent transcript Neighboring gene cell cycle exit and neuronal differentiation 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34283, FLJ35497, MGC131881, MGC138350

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glyoxalase III activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in lactate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
glutamine amidotransferase-like class 1 domain-containing protein 1
Names
Parkinson disease 7 domain containing 1
glutamine amidotransferase like class 1 domain containing 1
parkinson disease 7 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318818.2NP_001305747.1  glutamine amidotransferase-like class 1 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK293559, AP006621, BU625376
    UniProtKB/TrEMBL
    B7Z1J9
    Conserved Domains (2) summary
    cd03141
    Location:8166
    GATase1_Hsp31_like; Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein
    COG0693
    Location:31154
    ThiJ; Putative intracellular protease/amidase [General function prediction only]
  2. NM_001318820.2NP_001305749.1  glutamine amidotransferase-like class 1 domain-containing protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) lacks an alternate internal segment and is shorter at the C-terminus compared to variant 1.
    Source sequence(s)
    AK293559, AP006621, BC143416, BU625376, DC364167
    UniProtKB/TrEMBL
    B7Z1J9, B7ZKW3
    Conserved Domains (1) summary
    cl00020
    Location:12180
    GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
  3. NM_001318821.2NP_001305750.1  glutamine amidotransferase-like class 1 domain-containing protein 1 isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the C-terminus compared to isoform 1.
    Source sequence(s)
    AP006621, BC143418, BU625376, DC364167
    UniProtKB/TrEMBL
    B7ZKW4
    Conserved Domains (2) summary
    cd03141
    Location:12216
    GATase1_Hsp31_like; Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein
    COG0693
    Location:21204
    ThiJ; Putative intracellular protease/amidase [General function prediction only]
  4. NM_001318822.2NP_001305751.1  glutamine amidotransferase-like class 1 domain-containing protein 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate exons and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N- and C-termini and lacks an alternate in-frame segment compared to isoform 1.
    Source sequence(s)
    AP006621, BC143415, BU625376, DC364167
    Conserved Domains (1) summary
    cl00020
    Location:14130
    GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
  5. NM_001318823.2NP_001305752.1  glutamine amidotransferase-like class 1 domain-containing protein 1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) is shorter at the N- and C-termini compared to isoform 1.
    Source sequence(s)
    AP006621, BC143422, BU625376, DC364167
    Conserved Domains (2) summary
    cd03141
    Location:8166
    GATase1_Hsp31_like; Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein
    COG0693
    Location:31154
    ThiJ; Putative intracellular protease/amidase [General function prediction only]
  6. NM_001318824.2NP_001305753.1  glutamine amidotransferase-like class 1 domain-containing protein 1 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (7) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AP006621, BC143420, BU625376, DC364167
    Consensus CDS
    CCDS81530.1
    UniProtKB/Swiss-Prot
    Q8NB37
    Related
    ENSP00000431183.1, ENST00000524550.5
    Conserved Domains (1) summary
    cl00020
    Location:12180
    GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
  7. NM_001410955.1NP_001397884.1  glutamine amidotransferase-like class 1 domain-containing protein 1 isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AP006621
    Consensus CDS
    CCDS91400.1
    UniProtKB/TrEMBL
    E9PLI5
  8. NM_182612.4NP_872418.1  glutamine amidotransferase-like class 1 domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_872418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK293559, AP006621, BU625376, DC364167
    Consensus CDS
    CCDS7713.1
    UniProtKB/Swiss-Prot
    Q8NAE0, Q8NB37
    UniProtKB/TrEMBL
    B7Z1J9
    Related
    ENSP00000321691.8, ENST00000319863.13
    Conserved Domains (2) summary
    cd03141
    Location:12216
    GATase1_Hsp31_like; Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein
    COG0693
    Location:21204
    ThiJ; Putative intracellular protease/amidase [General function prediction only]

RNA

  1. NR_134867.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an alternate exon and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP006621, BC143423, BU625376, DC364167
  2. NR_134868.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP006621, BC143421, BU625376, DC364167

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    767222..777487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017668.2XP_016873157.1  glutamine amidotransferase-like class 1 domain-containing protein 1 isoform X5

  2. XM_047426880.1XP_047282836.1  glutamine amidotransferase-like class 1 domain-containing protein 1 isoform X4

  3. XM_011520064.3XP_011518366.1  glutamine amidotransferase-like class 1 domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    cd03141
    Location:12184
    GATase1_Hsp31_like; Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein
    COG0693
    Location:13187
    ThiJ; Putative intracellular protease/amidase [General function prediction only]
  4. XM_017017664.2XP_016873153.1  glutamine amidotransferase-like class 1 domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    E9PLI5
    Related
    ENSP00000433322.1, ENST00000526325.5
    Conserved Domains (2) summary
    COG0693
    Location:13178
    ThiJ; Putative intracellular protease/amidase [General function prediction only]
    cl00020
    Location:12150
    GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
  5. XM_017017662.2XP_016873151.1  glutamine amidotransferase-like class 1 domain-containing protein 1 isoform X1

RNA

  1. XR_242802.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    818734..828922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)