p38b p38b MAP kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: p38bprovided by FlyBase
Official Full Name: p38b MAP kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0024846
Locus tag: Dmel_CG7393
See related: AllianceGenome:FB:FBgn0024846
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 186F5S; anon-sts23; BG:DS00797.3; CG7393; D-p38; D-p38 MAPK; D-p38b; Dm p38b; Dmel\CG7393; Dmp38b; Dp38; dp38b; Dp38b; ESTS:186F5S; MAPK; Mpk34C; p38; P38; p38 beta; p38 MAPK; p38 MPK2b; p38B; P38B; p38beta; p38Kb; p38MAPK; p38[MAPK]
Summary: Enables MAP kinase activity. Involved in several processes, including defense response to other organism; determination of adult lifespan; and regulation of signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; gastric caecum; gut section; larval muscle cell; and somatic precursor cell. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 34D1-34D1; 2-49 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (13780689..13782611)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (13780689..13782611)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila p38 MAPK interacts with BAG-3/starvin to regulate age-dependent protein homeostasis.
Title: Drosophila p38 MAPK interacts with BAG-3/starvin to regulate age-dependent protein homeostasis.
Nutrition and PI3K/Akt signaling are required for p38-dependent regeneration.
Title: Nutrition and PI3K/Akt signaling are required for p38-dependent regeneration.
Evolutionarily conserved transcription factors drive the oxidative stress response in Drosophila.
Title: Evolutionarily conserved transcription factors drive the oxidative stress response in Drosophila.
These results illustrate a novel pro-tumourigenic crosstalk between the p38 MAPK pathway and JAK signalling in a Drosophila model of Myeloproliferative neoplasms.
Title: A Drosophila model of myeloproliferative neoplasm reveals a feed-forward loop in the JAK pathway mediated by p38 MAPK signalling.
ROS/JNK/p38/Upd stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Title: ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration.
Taken together, our findings indicate that the p38 MAP Kinase is an integral component of the core circadian clock of Drosophila in addition to playing a role in stress-input pathways.
Title: The MAP kinase p38 is part of Drosophila melanogaster's circadian clock.
data suggest that p38Kb may affect circadian locomotor rhythms through the regulation of multiple downstream pathways
Title: p38 MAP kinase regulates circadian rhythms in Drosophila.
Data show that the genetic interaction between p38b MAPK and Rack1 controls muscle aggregate formation, locomotor function, and longevity.
Title: In vivo interaction proteomics reveal a novel p38 mitogen-activated protein kinase/Rack1 pathway regulating proteostasis in Drosophila muscle.
The interaction of any of several Drosophila Delta class glutathione transferases and p38b mitogen-activated protein kinase can affect the substrate specificity of either enzyme, which suggests induced conformational changes affecting catalysis.
Title: Mitogen-activated protein kinase p38b interaction with delta class glutathione transferases from the fruit fly, Drosophila melanogaster.
found a correlation between the depth of integration of individual p38 kinases into the protein interaction network and their functional significance; propose a central role of p38b in the p38 signaling module with p38a and p38c playing more peripheral auxiliary roles
Title: High-resolution protein interaction map of the Drosophila melanogaster p38 mitogen-activated protein kinases reveals limited functional redundancy.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to arsenic-containing substance	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in paracrine signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of actin filament polymerization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell size	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of adult chitin-containing cuticle pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to salt stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: p38b MAP kinase

Names: CG7393-PA; p38 MAP kinase; p38 mitogen-activated protein kinase; p38b-PA; stress-activated p38b MAP kinase

NP_477361.1

EC 2.7.11.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

13780689..13782611

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058013.5 → NP_477361.1 p38b MAP kinase [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477361.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61443

Related

FBpp0080111

Conserved Domains (2) summary

cd07851
Location:8 → 353

STKc_p38; Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase

smart00220
Location:24 → 311

S_TKc; Serine/Threonine protein kinases, catalytic domain