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selenoh selenoprotein H [ Danio rerio (zebrafish) ]

Gene ID: 347743, updated on 27-Mar-2024

Summary

Official Symbol
selenohprovided by ZNC
Official Full Name
selenoprotein Hprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030411-2
See related
Ensembl:ENSDARG00000093022 AllianceGenome:ZFIN:ZDB-GENE-030411-2
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
selh; seph; cb697; wu:fa11g07; wu:fb23d03
Summary
This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase; and in mammals, it has been shown to protect neurons against UVB-induced damage, promote mitochondrial biogenesis, and suppress cellular senescence. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2017]
Orthologs
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Genomic context

See selenoh in Genome Data Viewer
Location:
chromosome: 8
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (7316622..7317434)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (7297891..7298703)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 6a Neighboring gene glutamate receptor interacting protein 2a Neighboring gene ssu-2 homolog, related sequence 1 Neighboring gene histone H3-like centromeric protein A Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor, like Neighboring gene LHFPL tetraspan subfamily member 4b

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

General protein information

Preferred Names
selenoprotein H
Names
etID39515.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178133.3NP_835234.2  selenoprotein H

    Status: REVIEWED

    Source sequence(s)
    CT670471, EH510258
    UniProtKB/TrEMBL
    A0A8M1PAE4
    Related
    ENSDARP00000122778.1, ENSDART00000140874.2
    Conserved Domains (1) summary
    cl01407
    Location:40121
    Rdx; Rdx family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    7316622..7317434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)