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SERINC2 serine incorporator 2 [ Homo sapiens (human) ]

Gene ID: 347735, updated on 22-Sep-2022

Summary

Official Symbol
SERINC2provided by HGNC
Official Full Name
serine incorporator 2provided by HGNC
Primary source
HGNC:HGNC:23231
See related
Ensembl:ENSG00000168528 MIM:614549; AllianceGenome:HGNC:23231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TDE2; TDE2L; FKSG84; PRO0899
Summary
Predicted to be involved in several processes, including phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; and positive regulation of serine C-palmitoyltransferase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in urinary bladder (RPKM 35.4), colon (RPKM 35.3) and 17 other tissues See more
Orthologs
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Genomic context

See SERINC2 in Genome Data Viewer
Location:
1p35.2
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (31409777..31434678)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (31262102..31291896)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (31882624..31907525)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378623 Neighboring gene Sharpr-MPRA regulatory region 2178 Neighboring gene uncharacterized LOC124903900 Neighboring gene MS1 minisatellite repeat instability region Neighboring gene uncharacterized LOC105378625 Neighboring gene uncharacterized LOC105379772

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC90340

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in phosphatidylserine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine incorporator 2
Names
tumor differentially expressed protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199037.2NP_001185966.1  serine incorporator 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon compared to variant 1. The resulting isoform (3) has a longer and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC114494, AK298512, BC007375, BC084580, BM924335, DC363849
    Consensus CDS
    CCDS55584.1
    UniProtKB/Swiss-Prot
    Q96SA4
    UniProtKB/TrEMBL
    Q96IM8
    Related
    ENSP00000444307.1, ENST00000536859.5
    Conserved Domains (1) summary
    pfam03348
    Location:21457
    Serinc; Serine incorporator (Serinc)
  2. NM_001199038.2NP_001185967.1  serine incorporator 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' sequence compared to variant 1. The resulting isoform (4) has a longer and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK127659, BC007375, BC084580, BM924335
    Consensus CDS
    CCDS55583.1
    UniProtKB/Swiss-Prot
    Q96SA4
    UniProtKB/TrEMBL
    Q96IM8
    Related
    ENSP00000362814.1, ENST00000373710.5
    Conserved Domains (1) summary
    pfam03348
    Location:26462
    Serinc; Serine incorporator (Serinc)
  3. NM_001199039.2NP_001185968.1  serine incorporator 2 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate 5' exon, resulting in a downstream AUG start codon, compared to variant 1. The resulting isoform (5) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC114494, AK093784, BC007375, BC084580
    UniProtKB/Swiss-Prot
    Q96SA4
    UniProtKB/TrEMBL
    Q96IM8
    Related
    ENST00000491976.1
    Conserved Domains (1) summary
    pfam03348
    Location:1398
    Serinc; Serine incorporator (Serinc)
  4. NM_018565.4NP_061035.2  serine incorporator 2 isoform 2

    See identical proteins and their annotated locations for NP_061035.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon compared to variant 1. The resulting isoform (2) has a longer and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK316357, BC007375, BC084580, BM924335
    Consensus CDS
    CCDS55585.1
    UniProtKB/Swiss-Prot
    Q96SA4
    UniProtKB/TrEMBL
    Q96IM8
    Related
    ENSP00000439048.1, ENST00000536384.2
    Conserved Domains (1) summary
    pfam03348
    Location:21457
    Serinc; Serine incorporator (Serinc)
  5. NM_178865.5NP_849196.2  serine incorporator 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_849196.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is a predominant transcript and encodes isoform (1).
    Source sequence(s)
    AK127659, AY094595, BC007375, BC084580, BM924335
    Consensus CDS
    CCDS30662.1
    UniProtKB/Swiss-Prot
    Q86Y23, Q96SA4
    UniProtKB/TrEMBL
    Q96IM8
    Related
    ENSP00000362813.3, ENST00000373709.8
    Conserved Domains (1) summary
    pfam03348
    Location:17453
    Serinc; Serine incorporator (Serinc)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    31409777..31434678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    31262102..31291896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)