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TUBB2B tubulin beta 2B class IIb [ Homo sapiens (human) ]

Gene ID: 347733, updated on 7-Jun-2020

Summary

Official Symbol
TUBB2Bprovided by HGNC
Official Full Name
tubulin beta 2B class IIbprovided by HGNC
Primary source
HGNC:HGNC:30829
See related
Ensembl:ENSG00000137285 MIM:612850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDCBM7; PMGYSA; bA506K6.1
Summary
The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]
Expression
Biased expression in brain (RPKM 233.4), bone marrow (RPKM 22.7) and 11 other tissues See more
Orthologs

Genomic context

See TUBB2B in Genome Data Viewer
Location:
6p25.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (3224277..3227653, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (3224495..3227968, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2525 Neighboring gene Sharpr-MPRA regulatory region 8505 Neighboring gene uncharacterized LOC100422781 Neighboring gene proteasome assembly chaperone 4 Neighboring gene solute carrier family 22 member 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, tubulin beta 2B class Iib, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria PubMed
tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8685, FLJ98847, DKFZp566F223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
embryonic brain development IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based process IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
tubulin beta-2B chain
Names
class II beta-tubulin isotype
class IIb beta-tubulin
epididymis secretory sperm binding protein
tubulin, beta 2B
tubulin, beta polypeptide paralog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016715.1 RefSeqGene

    Range
    5082..8458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178012.5NP_821080.1  tubulin beta-2B chain

    See identical proteins and their annotated locations for NP_821080.1

    Status: REVIEWED

    Source sequence(s)
    BC001352, BC063610, BX419454
    Consensus CDS
    CCDS4485.1
    UniProtKB/Swiss-Prot
    Q9BVA1
    Related
    ENSP00000259818.6, ENST00000259818.8
    Conserved Domains (1) summary
    PLN00220
    Location:1430
    PLN00220; tubulin beta chain; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    3224277..3227653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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