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CATSPER3 cation channel sperm associated 3 [ Homo sapiens (human) ]

Gene ID: 347732, updated on 17-Jun-2019

Summary

Official Symbol
CATSPER3provided by HGNC
Official Full Name
cation channel sperm associated 3provided by HGNC
Primary source
HGNC:HGNC:20819
See related
Ensembl:ENSG00000152705 MIM:609120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CACRC
Expression
Biased expression in testis (RPKM 12.5) and kidney (RPKM 0.5) See more
Orthologs

Genomic context

See CATSPER3 in Genome Data Viewer
Location:
5q31.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (134967907..135011696)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (134303596..134347397)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene pterin-4 alpha-carbinolamine dehydratase 2 Neighboring gene MT-ND4 pseudogene 12 Neighboring gene MT-ND3 pseudogene 25 Neighboring gene uncharacterized LOC107986452 Neighboring gene chromosome 5 open reading frame 66 Neighboring gene paired like homeodomain 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variants associated with disordered eating.
NHGRI GWA Catalog
Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.
NHGRI GWA Catalog
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of cation channel sperm associated 3 protein (CATSPER3) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Fertilization, organism-specific biosystem (from REACTOME)
    Fertilization, organism-specific biosystemMammalian fertilization comprises sperm migration through the female reproductive tract, biochemical and morphological changes to sperm, and sperm-egg interaction in the oviduct. Although the broad c...
  • Reproduction, organism-specific biosystem (from REACTOME)
    Reproduction, organism-specific biosystemHuman reproduction mixes the genomes of two individuals creating a new organism. The offspring individuals produced by sexual reproduction differ from their parents and from their siblings. Reproduct...
  • Sperm Motility And Taxes, organism-specific biosystem (from REACTOME)
    Sperm Motility And Taxes, organism-specific biosystemA series of receptor signaling pathways potentially govern chemical communication between sperm and egg, chemotactically guiding incoming sperm towards the oocyte. Though several substances are confi...

General gene information

Markers

Potential readthrough

Included gene: PCBD2

Homology

Clone Names

  • MGC126741

Gene Ontology Provided by GOA

Function Evidence Code Pubs
voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
response to progesterone TAS
Traceable Author Statement
more info
 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
sperm capacitation IEA
Inferred from Electronic Annotation
more info
 
sperm-egg recognition TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
CatSper complex ISS
Inferred from Sequence or Structural Similarity
more info
 
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
motile cilium IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cation channel sperm-associated protein 3
Names
ca(v)-like protein
calcium channel repeat containing 1
one-repeat calcium channel-like protein
putative ion channel CatSper3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178019.3NP_821138.1  cation channel sperm-associated protein 3

    See identical proteins and their annotated locations for NP_821138.1

    Status: VALIDATED

    Source sequence(s)
    AW008956, BC101692, BI827754
    Consensus CDS
    CCDS4181.1
    UniProtKB/Swiss-Prot
    Q86XQ3
    Related
    ENSP00000282611.6, ENST00000282611.8
    Conserved Domains (1) summary
    pfam00520
    Location:72269
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    134967907..135011696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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