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TUBB8 tubulin beta 8 class VIII [ Homo sapiens (human) ]

Gene ID: 347688, updated on 22-Aug-2021

Summary

Official Symbol
TUBB8provided by HGNC
Official Full Name
tubulin beta 8 class VIIIprovided by HGNC
Primary source
HGNC:HGNC:20773
See related
Ensembl:ENSG00000261456 MIM:616768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OOMD; OOMD2; bA631M21.2
Summary
The protein encoded by this gene represents the primary beta-tubulin subunit of oocytes and the early embryo. Defects in this gene, which is primate-specific, are a cause of oocyte maturation defect 2 and infertility. [provided by RefSeq, Mar 2016]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See TUBB8 in Genome Data Viewer
Location:
10p15.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (46437..76621, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (92828..95236, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723376 Neighboring gene interleukin 9 receptor pseudogene 2 Neighboring gene zinc finger MYND-type containing 11 Neighboring gene DEAD-box helicase 20 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev Rev acts to depolymerize microtubules that are formed by tubulin, an effect that is observed during HIV-1 infection PubMed
Tat tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed
tat HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40100, RP11-631M21.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spindle assembly involved in female meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tubulin beta-8 chain
Names
HSA10p15 beta-tubulin 4Q

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046777.1 RefSeqGene

    Range
    32218..34568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001389618.1NP_001376547.1  tubulin beta-8 chain isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL713922
    Conserved Domains (1) summary
    PLN00220
    Location:1355
    PLN00220; tubulin beta chain; Provisional
  2. NM_001389619.1NP_001376548.1  tubulin beta-8 chain isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL713922
    Conserved Domains (1) summary
    PLN00220
    Location:1355
    PLN00220; tubulin beta chain; Provisional
  3. NM_177987.3NP_817124.1  tubulin beta-8 chain isoform 1

    See identical proteins and their annotated locations for NP_817124.1

    Status: REVIEWED

    Source sequence(s)
    AL713922
    Consensus CDS
    CCDS7051.1
    UniProtKB/Swiss-Prot
    Q3ZCM7
    Related
    ENSP00000456206.2, ENST00000568584.6
    Conserved Domains (2) summary
    PTZ00010
    Location:1427
    PTZ00010; tubulin beta chain; Provisional
    cd02187
    Location:2426
    beta_tubulin; The beta-tubulin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    46437..76621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519460.2XP_011517762.1  tubulin beta-8 chain isoform X2

    Conserved Domains (1) summary
    cd02187
    Location:10273
    beta_tubulin; The beta-tubulin family
  2. XM_017016193.2XP_016871682.1  tubulin beta-8 chain isoform X1

  3. XM_017016192.2XP_016871681.1  tubulin beta-8 chain isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001164154.1: Suppressed sequence

    Description
    NM_001164154.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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