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IGBP1 immunoglobulin binding protein 1 [ Homo sapiens (human) ]

Gene ID: 3476, updated on 20-Dec-2019

Summary

Official Symbol
IGBP1provided by HGNC
Official Full Name
immunoglobulin binding protein 1provided by HGNC
Primary source
HGNC:HGNC:5461
See related
Ensembl:ENSG00000089289 MIM:300139
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IBP1; alpha4; ALPHA-4
Summary
The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 49.2), thyroid (RPKM 31.5) and 25 other tissues See more
Orthologs

Genomic context

See IGBP1 in Genome Data Viewer
Location:
Xq13.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (70133447..70166324)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69353318..69386174)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MT-ND5 pseudogene 39 Neighboring gene MT-ND4 pseudogene 31 Neighboring gene uncharacterized LOC107985683 Neighboring gene diacylglycerol O-acyltransferase 2 like 6 Neighboring gene RNA, 7SL, cytoplasmic 581, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 2A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
immunoglobulin-binding protein 1
Names
B cell signal transduction molecule alpha 4
CD79a-binding protein 1
bA351K23.1 (immunoglobulin binding protein 1 (CD79A) )
immunoglobulin (CD79A) binding protein 1
protein alpha-4
protein phosphatase 2/4/6 regulatory subunit
protein phosphatase 2A, regulatory subunit alpha-4
renal carcinoma antigen NY-REN-16

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012084.1 RefSeqGene

    Range
    4980..37857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001370192.1NP_001357121.1  immunoglobulin-binding protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL139111, AL158141
    Conserved Domains (1) summary
    pfam04177
    Location:12328
    TAP42; TAP42-like family
  2. NM_001370193.1NP_001357122.1  immunoglobulin-binding protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL139111, AL158141
    Conserved Domains (1) summary
    pfam04177
    Location:12328
    TAP42; TAP42-like family
  3. NM_001370194.1NP_001357123.1  immunoglobulin-binding protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL139111, AL158141
    Conserved Domains (1) summary
    pfam04177
    Location:12236
    TAP42; TAP42-like family
  4. NM_001551.3NP_001542.1  immunoglobulin-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001542.1

    Status: REVIEWED

    Source sequence(s)
    AL158141, BC004137
    Consensus CDS
    CCDS14396.1
    UniProtKB/Swiss-Prot
    P78318
    Related
    ENSP00000348784.4, ENST00000356413.5
    Conserved Domains (1) summary
    pfam04177
    Location:12328
    TAP42; TAP42-like family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    70133447..70166324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029489.1XP_016884978.1  immunoglobulin-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P78318
    Related
    ENSP00000363661.5, ENST00000342206.10
    Conserved Domains (1) summary
    pfam04177
    Location:12328
    TAP42; TAP42-like family

RNA

  1. XR_938398.1 RNA Sequence

  2. XR_002958775.1 RNA Sequence

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