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ARSH arylsulfatase family member H [ Homo sapiens (human) ]

Gene ID: 347527, updated on 23-Nov-2021

Summary

Official Symbol
ARSHprovided by HGNC
Official Full Name
arylsulfatase family member Hprovided by HGNC
Primary source
HGNC:HGNC:32488
See related
Ensembl:ENSG00000205667 MIM:300586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
sulfatase
Summary
Sulfatases, such as ARSH, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ARSH in Genome Data Viewer
Location:
Xp22.33
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (3006546..3034111)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (2924587..2952152)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ARSD antisense RNA 1 Neighboring gene arylsulfatase D Neighboring gene arylsulfatase L Neighboring gene arylsulfatase F Neighboring gene RNA, 7SL, cytoplasmic 578, pseudogene Neighboring gene ribosomal protein S24 pseudogene 21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arylsulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arylsulfatase activity TAS
Traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011719.2NP_001011719.1  arylsulfatase H

    See identical proteins and their annotated locations for NP_001011719.1

    Status: VALIDATED

    Source sequence(s)
    AC112653, AY875940
    Consensus CDS
    CCDS35198.1
    UniProtKB/Swiss-Prot
    Q5FYA8
    Related
    ENSP00000370522.3, ENST00000381130.3
    Conserved Domains (2) summary
    COG3119
    Location:6437
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:6530
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    3006546..3034111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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