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KIF24 kinesin family member 24 [ Homo sapiens (human) ]

Gene ID: 347240, updated on 21-Dec-2019

Summary

Official Symbol
KIF24provided by HGNC
Official Full Name
kinesin family member 24provided by HGNC
Primary source
HGNC:HGNC:19916
See related
Ensembl:ENSG00000186638 MIM:613747
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf48; bA571F15.4
Summary
This gene encodes a member of the kinesin superfamily of microtubule-based motor proteins which are involved in the intracellular transport of membranous organelles, protein complexes, and mRNAs. They also play critical roles in mitosis, morphogenesis, and signal transduction. The encoded protein contains an N-terminal sterile alpha motif (SAM) domain and an ATP-binding kinesin motor domain. It binds centriolar coiled coil protein 110 and centrosomal protein 97 and localizes to the mother centriole to regulate ciliogenesis by controlling microtubule polymerization. [provided by RefSeq, Mar 2017]
Expression
Broad expression in testis (RPKM 7.5), bone marrow (RPKM 4.2) and 25 other tissues See more
Orthologs

Genomic context

See KIF24 in Genome Data Viewer
Location:
9p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (34252033..34333520, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34252378..34329198, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ubiquitin associated protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 282 Neighboring gene ribosomal protein S8 pseudogene 9 Neighboring gene RNA, U2 small nuclear 50, pseudogene Neighboring gene serpin family H member 1 pseudogene 1 Neighboring gene nudix hydrolase 2 Neighboring gene myogenesis regulating glycosidase (putative) Neighboring gene chromosome 9 open reading frame 24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10933, FLJ43884, MGC125677, MGC125678

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
centriole IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053094.1 RefSeqGene

    Range
    8705..85593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_194313.4NP_919289.2  kinesin-like protein KIF24

    See identical proteins and their annotated locations for NP_919289.2

    Status: REVIEWED

    Source sequence(s)
    AK125180, AL353662, BC110502, BE856625, BF895212, BP871643, BU660279, DA906271, DT932659, DV080193, DV080194, HY066968
    Consensus CDS
    CCDS6551.2
    UniProtKB/Swiss-Prot
    Q5T7B8
    Related
    ENSP00000384433.1, ENST00000402558.6
    Conserved Domains (3) summary
    cd09541
    Location:362
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cd01367
    Location:223544
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:229545
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    34252033..34333520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517863.3XP_011516165.1  kinesin-like protein KIF24 isoform X2

    See identical proteins and their annotated locations for XP_011516165.1

    UniProtKB/Swiss-Prot
    Q5T7B8
    Conserved Domains (3) summary
    cd09541
    Location:362
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cd01367
    Location:223544
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:229545
    Kinesin; Kinesin motor domain
  2. XM_024447533.1XP_024303301.1  kinesin-like protein KIF24 isoform X4

    Conserved Domains (1) summary
    cl22853
    Location:15183
    Motor_domain; Myosin and Kinesin motor domain
  3. XM_017014698.2XP_016870187.1  kinesin-like protein KIF24 isoform X3

    Conserved Domains (2) summary
    cd01367
    Location:11255
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:17256
    Kinesin; Kinesin motor domain
  4. XM_011517861.2XP_011516163.1  kinesin-like protein KIF24 isoform X1

    See identical proteins and their annotated locations for XP_011516163.1

    Conserved Domains (3) summary
    cd09541
    Location:3493
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cd01367
    Location:254575
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:260576
    Kinesin; Kinesin motor domain
  5. XM_017014697.2XP_016870186.1  kinesin-like protein KIF24 isoform X2

    UniProtKB/Swiss-Prot
    Q5T7B8
    Conserved Domains (3) summary
    cd09541
    Location:362
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cd01367
    Location:223544
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:229545
    Kinesin; Kinesin motor domain
  6. XM_006716764.3XP_006716827.1  kinesin-like protein KIF24 isoform X5

    Conserved Domains (1) summary
    cl22853
    Location:4786
    Motor_domain; Myosin and Kinesin motor domain
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