U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

OR1B1 olfactory receptor family 1 subfamily B member 1 [ Homo sapiens (human) ]

Gene ID: 347169, updated on 24-Sep-2022

Summary

Official Symbol
OR1B1provided by HGNC
Official Full Name
olfactory receptor family 1 subfamily B member 1provided by HGNC
Primary source
HGNC:HGNC:8181
See related
Ensembl:ENSG00000280094 AllianceGenome:HGNC:8181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR9-B; OR9-26
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See OR1B1 in Genome Data Viewer
Location:
9q33.2
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (122628069..122657626, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (134825399..134854951, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125390348..125419905, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902265 Neighboring gene olfactory receptor family 1 subfamily H member 1 pseudogene Neighboring gene olfactory receptor family 1 subfamily Q member 1 Neighboring gene olfactory receptor family 1 subfamily L member 1 Neighboring gene olfactory receptor family 1 subfamily L member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
olfactory receptor 1B1
Names
olfactory receptor 9-B
olfactory receptor OR9-26

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004450.3NP_001004450.2  olfactory receptor 1B1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the protein-coding allele encoded by the GRCh38 reference genome.
    Source sequence(s)
    AL162254
    Related
    ENSP00000485577.1, ENST00000623530.1
    Conserved Domains (1) summary
    cd15235
    Location:25306
    7tmA_OR1A-like; olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001409693.1NP_001396622.1  olfactory receptor 1B1

    Status: VALIDATED

    Description
    Transcript Variant: This variant 2, coding) represents the protein-coding allele encoded by the GRCh38 reference genome.
    Source sequence(s)
    AL162254

RNA

  1. NR_178052.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) uses the same exon combination as variant 1, coding but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because a frameshift in the N-terminus results in a premature stop codon.
    Source sequence(s)
    CP068269
  2. NR_178053.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, non-coding) uses the same exon combination as variant 2, coding but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because a frameshift in the N-terminus results in a premature stop codon.
    Source sequence(s)
    CP068269

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    122628069..122657626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    134825399..134854951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)