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ADGRD2 adhesion G protein-coupled receptor D2 [ Homo sapiens (human) ]

Gene ID: 347088, updated on 25-Jan-2022

Summary

Official Symbol
ADGRD2provided by HGNC
Official Full Name
adhesion G protein-coupled receptor D2provided by HGNC
Primary source
HGNC:HGNC:18651
See related
Ensembl:ENSG00000180264 AllianceGenome:HGNC:18651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR24; GPR144
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ADGRD2 in Genome Data Viewer
Location:
9q33.3
Exon count:
27
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (124450451..124478580)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376269 Neighboring gene NIMA related kinase 6 Neighboring gene uncharacterized LOC100129034 Neighboring gene proteasome 20S subunit beta 7 Neighboring gene uncharacterized LOC105376270 Neighboring gene NR5A1 5' promoter region Neighboring gene nuclear receptor subfamily 5 group A member 1 Neighboring gene nuclear receptor subfamily 6 group A member 1 Neighboring gene RAN binding protein 1 pseudogene

Genomic regions, transcripts, and products

Genomic Sequence:
NC_000009.12 Chromosome 9 Reference GRCh38.p13 Primary Assembly

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
adhesion G-protein coupled receptor D2
Names
G protein-coupled receptor PGR24
G-protein coupled receptor 144
G-protein coupled receptor GPR144

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395425.1NP_001382354.1  adhesion G-protein coupled receptor D2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL137846
    Related
    ENSP00000335156.2, ENST00000334810.5
    Conserved Domains (4) summary
    cd00037
    Location:5073
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd15255
    Location:692954
    7tmB2_GPR144; orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02559
    Location:646685
    GPS; GPCR proteolysis site, GPS, motif
    cl22861
    Location:111297
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    124450451..124478580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717348.3XP_006717411.2  adhesion G-protein coupled receptor D2 isoform X1

    Conserved Domains (4) summary
    cd00037
    Location:6992
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    pfam01825
    Location:621653
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:668908
    7tm_4; Olfactory receptor
    cl22861
    Location:130316
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RNA

  1. XR_930339.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001161808.1: Suppressed sequence

    Description
    NM_001161808.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_182611.2: Suppressed sequence

    Description
    NM_182611.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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