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Sirt1 Sirtuin 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34708, updated on 9-Oct-2018

Summary

Official Symbol
Sirt1provided by FlyBase
Official Full Name
Sirtuin 1provided by FlyBase
Primary source
FLYBASE:FBgn0024291
Locus tag
Dmel_CG5216
Gene type
protein coding
RNA name
sirtuin 1
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LD38188; CG5216; D.mel1; Dmel\CG5216; dmSRT406; dsir2; dSir2; dSIR2; DSir2; l(2)05326; sir2; Sir2; SIR2; Sir2L

Genomic context

See Sirt1 in Genome Data Viewer
Location:
34A7-34A7; 2-47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13165564..13169551)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13165564..13169551)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Pk34A Neighboring gene kumgang Neighboring gene DnaJ homolog Neighboring gene Scm-related gene containing four mbt domains Neighboring gene ncRNA Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K9 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bHLH transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein C-terminus binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein domain specific binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of feeding behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of histone acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear euchromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sirtuin 1
Names
CG5216-PA
Sir2
Sirt1-PA
silent information regulator 2
NP_477351.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13165564..13169551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058003.4NP_477351.1  sirtuin 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477351.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VK34
    Related
    FBpp0080015, FBtr0080434
    Conserved Domains (2) summary
    cd01408
    Location:222476
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    pfam04574
    Location:202228
    DUF592; Protein of unknown function (DUF592)
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