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PRSS51 serine protease 51 [ Homo sapiens (human) ]

Gene ID: 346702, updated on 6-Jun-2024

Summary

Official Symbol
PRSS51provided by HGNC
Official Full Name
serine protease 51provided by HGNC
Primary source
HGNC:HGNC:37321
See related
Ensembl:ENSG00000253649 AllianceGenome:HGNC:37321
Gene type
protein coding
RefSeq status
MODEL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See PRSS51 in Genome Data Viewer
Location:
8p23.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (10481293..10547723, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (9191405..9257428)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901887 Neighboring gene long intergenic non-protein coding RNA 3022 Neighboring gene RNA, U6 small nuclear 729, pseudogene Neighboring gene serine protease 52, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10382638-10383436 Neighboring gene serine protease 55 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10406483-10407477 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:10412556-10413270 Neighboring gene uncharacterized LOC105379237 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10449944-10450820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10459109-10459704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10459705-10460299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10469845-10470570 Neighboring gene RP1 like 1 Neighboring gene MPRA-validated peak6901 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10489151-10489860 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10493333-10494238 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10494239-10495144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10503027-10503883

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease-like protein 51
Names
protease, serine 51

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    10481293..10547723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422510.1XP_047278466.1  serine protease-like protein 51 isoform X2

  2. XM_047422509.1XP_047278465.1  serine protease-like protein 51 isoform X1

    UniProtKB/TrEMBL
    A0A2R8YGP0, A0A3B3ISV0
    Related
    ENSP00000497613.1, ENST00000647727.1

RNA

  1. XR_007060820.1 RNA Sequence

  2. XR_007060819.1 RNA Sequence

  3. XR_007060818.1 RNA Sequence

  4. XR_007060817.1 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    2861848..2865294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007069084.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    9191405..9257428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445280.1XP_047301236.1  serine protease-like protein 51 isoform X2

  2. XM_047445278.1XP_047301234.1  serine protease-like protein 51 isoform X3

  3. XM_047445277.1XP_047301233.1  serine protease-like protein 51 isoform X1

    UniProtKB/TrEMBL
    A0A2R8YGP0
  4. XM_047445279.1XP_047301235.1  serine protease-like protein 51 isoform X2

RNA

  1. XR_007078693.1 RNA Sequence

  2. XR_007078691.1 RNA Sequence

  3. XR_007078689.1 RNA Sequence

  4. XR_007078690.1 RNA Sequence

  5. XR_007078692.1 RNA Sequence