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IFNW1 interferon omega 1 [ Homo sapiens (human) ]

Gene ID: 3467, updated on 11-Jun-2021

Summary

Official Symbol
IFNW1provided by HGNC
Official Full Name
interferon omega 1provided by HGNC
Primary source
HGNC:HGNC:5448
See related
Ensembl:ENSG00000177047 MIM:147553
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is an interferon and possesses antiviral activity. The encoded protein binds to the interferon alpha/beta receptor but not to the interferon gamma receptor. This intronless gene has several pseudogenes spread throughout the genome. [provided by RefSeq, Nov 2015]
Orthologs
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Genomic context

See IFNW1 in Genome Data Viewer
Location:
9p21.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (21140632..21141832, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (21140631..21141900, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene interferon beta 1 Neighboring gene interferon omega 1 pseudogene 4 Neighboring gene interferon alpha 21 Neighboring gene interferon omega 1 pseudogene 15

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables type I interferon receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in T cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in natural killer cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell cycle TAS
Traceable Author Statement
more info
PubMed 
involved_in response to exogenous dsRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to virus TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interferon omega-1
Names
IFN-omega 1, interferon omega-1
interferon alpha-II-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002177.3NP_002168.1  interferon omega-1 precursor

    See identical proteins and their annotated locations for NP_002168.1

    Status: REVIEWED

    Source sequence(s)
    AI860608, X02669
    Consensus CDS
    CCDS6496.1
    UniProtKB/Swiss-Prot
    P05000
    Related
    ENSP00000369578.2, ENST00000380229.4
    Conserved Domains (1) summary
    pfam00143
    Location:26185
    Interferon; Interferon alpha/beta domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    21140632..21141832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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