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STRA8 stimulated by retinoic acid 8 [ Homo sapiens (human) ]

Gene ID: 346673, updated on 23-Nov-2021

Summary

Official Symbol
STRA8provided by HGNC
Official Full Name
stimulated by retinoic acid 8provided by HGNC
Primary source
HGNC:HGNC:30653
See related
Ensembl:ENSG00000146857 MIM:609987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See STRA8 in Genome Data Viewer
Location:
7q33
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (135231915..135258663)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134916731..134943415)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cell cycle regulator of NHEJ Neighboring gene transmembrane protein 140 Neighboring gene WD repeat domain 91 Neighboring gene microRNA 6509 Neighboring gene uncharacterized LOC107984123 Neighboring gene solute carrier family 23 member 4, pseudogene Neighboring gene CCR4-NOT transcription complex subunit 4 Neighboring gene succinate dehydrogenase complex subunit D pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of meiosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of meiosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in oogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in oogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
stimulated by retinoic acid gene 8 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394401.1NP_001381330.1  stimulated by retinoic acid gene 8 protein homolog isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009542
    Conserved Domains (1) summary
    cl00081
    Location:3190
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  2. NM_182489.3NP_872295.2  stimulated by retinoic acid gene 8 protein homolog isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009542
    Consensus CDS
    CCDS5839.1
    Related
    ENSP00000499721.1, ENST00000667288.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    135231915..135258663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516137.2XP_011514439.1  stimulated by retinoic acid gene 8 protein homolog isoform X1

    See identical proteins and their annotated locations for XP_011514439.1

    Conserved Domains (1) summary
    cl00081
    Location:3190
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  2. XM_011516139.2XP_011514441.1  stimulated by retinoic acid gene 8 protein homolog isoform X1

    See identical proteins and their annotated locations for XP_011514441.1

    Conserved Domains (1) summary
    cl00081
    Location:3190
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  3. XM_017012150.1XP_016867639.1  stimulated by retinoic acid gene 8 protein homolog isoform X2

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