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rho-6 rhomboid-6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34640, updated on 6-Jul-2026
Official Symbol
rho-6provided by FlyBase
Official Full Name
rhomboid-6provided by FlyBase
Primary source
FLYBASE:FBgn0032415
Locus tag
Dmel_CG17212
See related
AllianceGenome:FB:FBgn0032415
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17212; Dmel\CG17212; rho 6; Rho-related [33C1]; rho6
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be located in membrane. Orthologous to human RHBDL1 (rhomboid like 1) and RHBDL3 (rhomboid like 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See rho-6 in Genome Data Viewer
Location:
33D2-33D2; 2-46 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12130516..12133411, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12130516..12133411, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phaedra 2 Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 33a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling. Guichard A, et al. Dev Biol, 2000 Oct 15. PMID 11023685
  2. A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands. Urban S, et al. EMBO J, 2002 Aug 15. PMID 12169630, Free PMC Article
  3. A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling. Wasserman JD, et al. Genes Dev, 2000 Jul 1. PMID 10887159, Free PMC Article
  4. Human BOULE gene rescues meiotic defects in infertile flies. Xu EY, et al. Hum Mol Genet, 2003 Jan 15. PMID 12499397
  5. Rhomboid proteins: conserved membrane proteases with divergent biological functions. Urban S. Genes Dev, 2006 Nov 15. PMID 17114579

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
rhomboid-6
Names
CG17212-PB
CG17212-PC
Rhomboid-6
rho-6-PB
rho-6-PC
NP_001285872.1
NP_788038.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12130516..12133411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298943.1 → NP_001285872.1  rhomboid-6, isoform C

    See identical proteins and their annotated locations for NP_001285872.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J9K6
    Conserved Domains (1) summary
    cl21536
    Location:106 → 132
    Rhomboid; Rhomboid family

  2. NM_176024.3 → NP_788038.1  rhomboid-6, isoform B

    See identical proteins and their annotated locations for NP_788038.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G2J602, Q86BL6
    Related
    FBpp0079942
    Conserved Domains (1) summary
    pfam01694
    Location:106 → 251
    Rhomboid; Rhomboid family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86BL6 Q86BL6
X2J9K6 X2J9K6

Gene LinkOut

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