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MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein [ Homo sapiens (human) ]

Gene ID: 345643, updated on 13-Mar-2020

Summary

Official Symbol
MCIDASprovided by HGNC
Official Full Name
multiciliate differentiation and DNA synthesis associated cell cycle proteinprovided by HGNC
Primary source
HGNC:HGNC:40050
See related
Ensembl:ENSG00000234602 MIM:614086
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCI; IDAS; MCIN; CILD42
Summary
This gene encodes a member of the geminin family of proteins. The encoded nuclear protein is required for the generation of multiciliated cells in respiratory epithelium. Mutations in this gene cause a rare mucociliary clearance disorder associated with recurring respiratory infections in human patients, known as reduced generation of multiple motile cilia (RGMC). [provided by RefSeq, Sep 2016]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See MCIDAS in Genome Data Viewer
Location:
5q11.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (55218791..55227315, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54515425..54523143, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cell division cycle 20B Neighboring gene microRNA 449b Neighboring gene microRNA 449c Neighboring gene cyclin O Neighboring gene DExH-box helicase 29 Neighboring gene uncharacterized LOC105378973

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
centriole assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
motile cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
multi-ciliated epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nuclear body IDA
Inferred from Direct Assay
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
multicilin
Names
multiciliate cell differentiation 1
protein Idas

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051620.1 RefSeqGene

    Range
    5001..12736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001190787.3NP_001177716.1  multicilin

    See identical proteins and their annotated locations for NP_001177716.1

    Status: REVIEWED

    Source sequence(s)
    AC091977
    Consensus CDS
    CCDS54853.1
    UniProtKB/Swiss-Prot
    D6RGH6
    Related
    ENSP00000426359.1, ENST00000513312.3
    Conserved Domains (1) summary
    pfam07412
    Location:180241
    Geminin; Geminin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    55218791..55227315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009439.2XP_016864928.1  multicilin isoform X1

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