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IFNB1 interferon beta 1 [ Homo sapiens (human) ]

Gene ID: 3456, updated on 3-Dec-2017
Official Symbol
IFNB1provided by HGNC
Official Full Name
interferon beta 1provided by HGNC
Primary source
HGNC:HGNC:5434
See related
Ensembl:ENSG00000171855 MIM:147640; Vega:OTTHUMG00000019652
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFB; IFF; IFNB; IFN-beta
Summary
This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]
Orthologs
Location:
9p21.3
Exon count:
1
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (21077105..21077963, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (21077104..21077943, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene 3-hydroxyacyl-CoA dehydratase 4 Neighboring gene uncharacterized LOC105375989 Neighboring gene interferon nu 1, pseudogene Neighboring gene interferon omega 1 Neighboring gene interferon alpha 21

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
HIV-1 replication upregulates the expression of MX2 and IFNB1 mRNA 24 hours after infection in monocyte-derived Langerhans cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 inhibits CpG-A-induced secretion of IFN-alpha and IFN-beta proteins in PBMCs PubMed
env HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs PubMed
env Sulfate containing galactolipids such as sulfatides on responder cells may be part of the HIV-1 gp120-membrane complex that initiates the induction of interferon (IFN) PubMed
env HIV-1 (possibly through the HIV-1 gp120 protein) induces low levels of IFN-beta in macrophages, and the IFN-beta plays an effective role in restriction of virus replication PubMed
Envelope transmembrane glycoprotein gp41 env IFN-beta inhibits the binding of soluble gp41 to T, B and monocyte cell lines PubMed
env HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells PubMed
Nef nef HIV-1 Nef myristoylation is required for the activation of IRF-3, leading to the synthesis of IFNbeta in monocytes-derived-macrophages PubMed
nef The acidic cluster (residues 64-69) of HIV-1 Nef is required for IRF-3 activation and IFNbeta production PubMed
Pr55(Gag) gag IFN-beta-induced expression of TRIM22 restricts HIV-1 replication. TRIM22 inhibits the budding of HIV-1 Gag-only particles PubMed
Tat tat HIV-1 Tat inhibits CpG-A-induced secretion of IFN-alpha and IFN-beta proteins in PBMCs PubMed
tat HIV-1 Tat downregulates the LPS-induction of IFN-beta and concomitantly upregulates IL-6 expression in primary blood monocytes/macrophages PubMed
tat HIV-1 Tat-induced SOCS3 expression inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages in a NF-kappaB-dependent manner PubMed
tat IFN treatment significantly reduces HIV-1 mRNA levels from a Tat defective provirus, suggesting Tat can overcome the inhibitory effects of IFN on HIV-1 replication PubMed
tat IFN beta is an effective inhibitor of HIV-1 Tat-stimulated growth, migration and morphogenesis of an endothelial cell line in vitro and of angiogenesis in vivo PubMed
tat HIV-1 Tat enhances translation of the interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase, suggesting interaction of Tat with interferons during HIV-1 replication PubMed
Vif vif MDDCs treated with HIV-1 DeltaVif mutant induce the expression of IFN-beta gene, suggesting that Vif inhibits IFN-beta induction from cells PubMed
Vpr vpr MDDCs treated with HIV-1 DeltaVpr mutant induce the expression of IFN-beta gene, suggesting that Vpr inhibits IFN-beta induction from cells PubMed
Vpu vpu HIV-1 Vpu inhibits IFN-beta promoter activity in an IRF3-independent manner. NF-kappaB-mediated enhancement of the IFN-beta promoter activity is inhibited by HIV-1 Vpu PubMed
vpu Vpu-mediated suppresion of IFNB (IFN-1) production requires engagement and activation of the LILRA4 (ILT7) plasmacytoid dendritic cell receptor by BST2 PubMed
vpu Vpu-mediated modulation of IFNB (IFN-1) production by plasmacytoid dendritric cells requires the presence of BST2 on infected donor cells PubMed
vpu Vpu attenuates IFNB (IFN-1) production upon sensing of HIV-infected cells by plasmacytoid dendritic cells PubMed
vpu Vpu modulates IFNB (IFN-1) production by PBMCs following contact with HIV-infected CD4+ T cells PubMed
vpu IFN-alpha and IFN-beta increase SCYL2 expression and the increase induces PP2A-mediated dephosphorylation of Vpu, suggesting that SCYL2 affects Vpu function through a phosphorylation-dependent mechanism PubMed
capsid gag Cells treatment with IFN-alpha and IFN-beta inhibit HIV-1 replication with decreased levels of p24 in a dose-dependent manner PubMed
reverse transcriptase gag-pol The reverse-transcribed viral DNA by HIV-1 RT is the trigger of IRF3 activation and IFN-beta production in HIV-1 infected human monocytic cell line THP1 PubMed

Go to the HIV-1, Human Interaction Database

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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC96956

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chloramphenicol O-acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
type I interferon receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
type I interferon receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
B cell activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
B cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
T cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cellular response to exogenous dsRNA TAS
Traceable Author Statement
more info
PubMed 
cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
PubMed 
defense response to virus TAS
Traceable Author Statement
more info
PubMed 
humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
natural killer cell activation NAS
Non-traceable Author Statement
more info
PubMed 
natural killer cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of T-helper 2 cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of innate immune response NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
regulation of MHC class I biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
regulation of receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of type I interferon-mediated signaling pathway TAS
Traceable Author Statement
more info
 
response to exogenous dsRNA IDA
Inferred from Direct Assay
more info
PubMed 
response to virus NAS
Non-traceable Author Statement
more info
PubMed 
type I interferon signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular region IC
Inferred by Curator
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
interferon beta
Names
fibroblast interferon
interferon, beta 1, fibroblast
interferon-beta

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002176.3NP_002167.1  interferon beta precursor

    See identical proteins and their annotated locations for NP_002167.1

    Status: REVIEWED

    Source sequence(s)
    AL390882, M28622
    Consensus CDS
    CCDS6495.1
    UniProtKB/Swiss-Prot
    P01574
    Related
    ENSP00000369581.2, OTTHUMP00000021131, ENST00000380232.3, OTTHUMT00000051881
    Conserved Domains (1) summary
    pfam00143
    Location:27185
    Interferon; Interferon alpha/beta domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

    Range
    21077105..21077963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    21076893..21077751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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