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PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 [ Homo sapiens (human) ]

Gene ID: 345557, updated on 5-Aug-2022

Summary

Official Symbol
PLCXD3provided by HGNC
Official Full Name
phosphatidylinositol specific phospholipase C X domain containing 3provided by HGNC
Primary source
HGNC:HGNC:31822
See related
Ensembl:ENSG00000182836 MIM:617016; AllianceGenome:HGNC:31822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid catabolic process and signal transduction. Predicted to be located in cytoplasm. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart (RPKM 12.4), ovary (RPKM 9.3) and 8 other tissues See more
Orthologs
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Genomic context

See PLCXD3 in Genome Data Viewer
Location:
5p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (41306952..41510601, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (41563425..41766981, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (41307054..41510703, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374739 Neighboring gene complement C6 Neighboring gene uncharacterized LOC124900969 Neighboring gene uncharacterized LOC102723740 Neighboring gene uncharacterized LOC105374740 Neighboring gene t-complex 1 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 14195 Neighboring gene 3-oxoacid CoA-transferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphoric diester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
PI-PLC X domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005473.3NP_001005473.1  PI-PLC X domain-containing protein 3

    See identical proteins and their annotated locations for NP_001005473.1

    Status: VALIDATED

    Source sequence(s)
    AC008830, AK127142, BX648329
    Consensus CDS
    CCDS34150.1
    UniProtKB/Swiss-Prot
    A6NL04, Q63HM9
    UniProtKB/TrEMBL
    B3KXD1
    Related
    ENSP00000367032.3, ENST00000377801.8
    Conserved Domains (1) summary
    cd08616
    Location:19311
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    41306952..41510601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009438.3XP_016864927.1  PI-PLC X domain-containing protein 3 isoform X1

    Conserved Domains (1) summary
    cd08616
    Location:1239
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    41563425..41766981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)