Format

Send to:

Choose Destination

ATP13A5 ATPase 13A5 [ Homo sapiens (human) ]

Gene ID: 344905, updated on 23-Nov-2021

Summary

Official Symbol
ATP13A5provided by HGNC
Official Full Name
ATPase 13A5provided by HGNC
Primary source
HGNC:HGNC:31789
See related
Ensembl:ENSG00000187527 MIM:619119
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the P5 subfamily of P-type transport ATPases. P-type ATPases form a large superfamily of cation and lipid pumps that transport inorganic cations and other substrates across cell membranes. P5 ATPases are localized to membranes of the endoplasmic reticulum (ER) and serve many important functions including transport of cargo proteins to the Golgi, glycosylation and cell wall biosynthesis, control of protein insertion orientation, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) degradation, and sensitivity to unfolded protein response (UPR) activators. The encoded protein is organized into three cytoplasmic domains (A, P, and N) and two membrane-embedded domains (T and S). The N-domain binds ATP and serves as a built-in protein kinase, which phosphorylates the P-domain. The A-domain is an intrinsic protein phosphatase, which dephosphorylates the P-domain once during each catalytic cycle. [provided by RefSeq, Jul 2017]
Expression
Biased expression in salivary gland (RPKM 2.0), skin (RPKM 0.9) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ATP13A5 in Genome Data Viewer
Location:
3q29
Exon count:
31
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (193274789..193378820, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (192992578..193096542, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374280 Neighboring gene uncharacterized protein MGC2889 Neighboring gene phospholipase A and acyltransferase 1 Neighboring gene ATP13A5 antisense RNA 1 Neighboring gene ATPase 13A4 Neighboring gene ATP13A4 antisense RNA 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ16025

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled cation transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ion transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
probable cation-transporting ATPase 13A5
Names
ATPase type 13A5
P5-ATPase
NP_940907.2
XP_011511072.1
XP_016861793.1
XP_016861794.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198505.4NP_940907.2  probable cation-transporting ATPase 13A5

    See identical proteins and their annotated locations for NP_940907.2

    Status: REVIEWED

    Source sequence(s)
    AC105057
    Consensus CDS
    CCDS33914.1
    UniProtKB/Swiss-Prot
    Q4VNC0
    Related
    ENSP00000341942.4, ENST00000342358.9
    Conserved Domains (6) summary
    COG4087
    Location:822871
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01657
    Location:181119
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:228471
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:170239
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:17137
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:595636
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    193274789..193378820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006304.1XP_016861793.1  probable cation-transporting ATPase 13A5 isoform X2

  2. XM_017006305.1XP_016861794.1  probable cation-transporting ATPase 13A5 isoform X3

  3. XM_011512770.2XP_011511072.1  probable cation-transporting ATPase 13A5 isoform X1

    Conserved Domains (6) summary
    COG4087
    Location:822871
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01494
    Location:230945
    ATPase_P-type; ATPase, P-type (transporting), HAD superfamily, subfamily IC
    pfam00122
    Location:228471
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:170239
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:17137
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:595636
    Cation_ATPase; Cation transport ATPase (P-type)
Support Center