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RTP2 receptor transporter protein 2 [ Homo sapiens (human) ]

Gene ID: 344892, updated on 17-Jun-2024

Summary

Official Symbol
RTP2provided by HGNC
Official Full Name
receptor transporter protein 2provided by HGNC
Primary source
HGNC:HGNC:32486
See related
Ensembl:ENSG00000198471 MIM:609138; AllianceGenome:HGNC:32486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Z3CXXC2
Summary
Enables olfactory receptor binding activity. Involved in protein insertion into membrane. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See RTP2 in Genome Data Viewer
Location:
3q27.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (187698259..187715691, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (190515702..190533149, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (187416047..187420345, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374262 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:187285231-187286214 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:187286215-187287197 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:187352529-187353028 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:187416261-187416442 Neighboring gene hCG1645011-like Neighboring gene somatostatin Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:187455905-187456884 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:187457386-187457561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:187458977-187459478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:187459479-187459978 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:187462369-187462894 Neighboring gene BCL6 transcription repressor Neighboring gene BCL6 antisense RNA 1 Neighboring gene uncharacterized LOC105374263

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC78665

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables olfactory receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in detection of chemical stimulus involved in sensory perception of bitter taste IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein insertion into membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein insertion into membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
receptor-transporting protein 2
Names
3CxxC-type zinc finger protein 2
receptor (chemosensory) transporter protein 2
zinc finger, 3CxxC-type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004312.2NP_001004312.2  receptor-transporting protein 2

    See identical proteins and their annotated locations for NP_001004312.2

    Status: VALIDATED

    Source sequence(s)
    AC072022, AY562236, BC068081
    Consensus CDS
    CCDS33911.1
    UniProtKB/Swiss-Prot
    Q5QGT7, Q6NVH4
    Related
    ENSP00000350976.1, ENST00000358241.1
    Conserved Domains (1) summary
    pfam13695
    Location:51161
    zf-3CxxC; Zinc-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    187698259..187715691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006302.2XP_016861791.1  receptor-transporting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5QGT7, Q6NVH4
    Conserved Domains (1) summary
    pfam13695
    Location:51161
    zf-3CxxC; Zinc-binding domain
  2. XM_017006301.2XP_016861790.1  receptor-transporting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5QGT7, Q6NVH4
    Conserved Domains (1) summary
    pfam13695
    Location:51161
    zf-3CxxC; Zinc-binding domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    190515702..190533149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346432.1XP_054202407.1  receptor-transporting protein 2 isoform X1

  2. XM_054346431.1XP_054202406.1  receptor-transporting protein 2 isoform X1