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GPR149 G protein-coupled receptor 149 [ Homo sapiens (human) ]

Gene ID: 344758, updated on 23-Nov-2021

Summary

Official Symbol
GPR149provided by HGNC
Official Full Name
G protein-coupled receptor 149provided by HGNC
Primary source
HGNC:HGNC:23627
See related
Ensembl:ENSG00000174948
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R35; IEDA; PGR10
Summary
This gene encodes a seven-transmembrane G protein coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A receptors which is important for efficient G protein-coupled signal transduction. Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. All GPCRs have a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See GPR149 in Genome Data Viewer
Location:
3q25.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (154334943..154430190, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (154052732..154147979, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 26 Neighboring gene uncharacterized LOC105374167 Neighboring gene DEAH-box helicase 36 Neighboring gene Sharpr-MPRA regulatory region 7914 Neighboring gene DEAD-box helicase 50 pseudogene 2 Neighboring gene dynein light chain LC8-type 1 pseudogene 5 Neighboring gene synaptophysin like 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in antral ovarian follicle growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ovulation IEA
Inferred from Electronic Annotation
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in preantral ovarian follicle growth IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable G-protein coupled receptor 149
Names
G protein-coupled receptor PGR10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038705.3NP_001033794.1  probable G-protein coupled receptor 149

    See identical proteins and their annotated locations for NP_001033794.1

    Status: REVIEWED

    Source sequence(s)
    AC092946, AC134026, BU743000, DQ318360
    Consensus CDS
    CCDS43162.1
    UniProtKB/Swiss-Prot
    Q86SP6
    UniProtKB/TrEMBL
    Q2MKA6
    Related
    ENSP00000374390.2, ENST00000389740.3
    Conserved Domains (1) summary
    cd15011
    Location:35374
    7tmA_GPR149; G protein-coupled receptor 149, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    154334943..154430190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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