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GPR148 G protein-coupled receptor 148 [ Homo sapiens (human) ]

Gene ID: 344561, updated on 22-Sep-2022

Summary

Official Symbol
GPR148provided by HGNC
Official Full Name
G protein-coupled receptor 148provided by HGNC
Primary source
HGNC:HGNC:23623
See related
Ensembl:ENSG00000173302 AllianceGenome:HGNC:23623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTR; PGR6
Summary
Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See GPR148 in Genome Data Viewer
Location:
2q21.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (130729070..130730336)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (131163223..131164489)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (131486643..131487909)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene LCR2q21.1 proximal recombination region Neighboring gene fatty acyl-CoA reductase 2 pseudogene 3 Neighboring gene Kruppel like factor 2 pseudogene 3 Neighboring gene uncharacterized LOC124907890 Neighboring gene APC membrane recruitment protein 3 Neighboring gene CYCS pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2018-04-05)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2018-04-05)

ClinGen Genome Curation Page

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 148
Names
G protein-coupled receptor PGR6
brain and testis restricted GPCR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207364.2NP_997247.2  probable G-protein coupled receptor 148

    See identical proteins and their annotated locations for NP_997247.2

    Status: VALIDATED

    Source sequence(s)
    AC140481, BC105013
    Consensus CDS
    CCDS2163.1
    UniProtKB/Swiss-Prot
    Q86U87, Q8TDV2
    Related
    ENSP00000308908.4, ENST00000309926.4
    Conserved Domains (1) summary
    pfam00001
    Location:69303
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    130729070..130730336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    131163223..131164489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)