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SH3RF3 SH3 domain containing ring finger 3 [ Homo sapiens (human) ]

Gene ID: 344558, updated on 26-Oct-2020

Summary

Official Symbol
SH3RF3provided by HGNC
Official Full Name
SH3 domain containing ring finger 3provided by HGNC
Primary source
HGNC:HGNC:24699
See related
Ensembl:ENSG00000172985 MIM:618933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POSH2; SH3MD4
Expression
Ubiquitous expression in testis (RPKM 1.9), gall bladder (RPKM 1.8) and 25 other tissues See more
Orthologs

Genomic context

See SH3RF3 in Genome Data Viewer
Location:
2q13
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (109129205..109504635)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (109745997..110107395) , (110259067..110262207)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 138 Neighboring gene ribosomal protein L39 pseudogene 16 Neighboring gene ectodysplasin A receptor Neighboring gene SH3RF3 antisense RNA 1 Neighboring gene microRNA 4265 Neighboring gene Sharpr-MPRA regulatory region 14332 Neighboring gene Sharpr-MPRA regulatory region 6940 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 9 Neighboring gene uncharacterized LOC107985773 Neighboring gene microRNA 4266 Neighboring gene Sharpr-MPRA regulatory region 2497 Neighboring gene septin 10 Neighboring gene ribosomal protein L37 pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase SH3RF3
Names
SH3 domain-containing RING finger protein 3
SH3 multiple domains 4
plenty of SH3s-2
NP_001092759.1
XP_011509411.1
XP_011509412.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099289.3NP_001092759.1  E3 ubiquitin-protein ligase SH3RF3 precursor

    See identical proteins and their annotated locations for NP_001092759.1

    Status: VALIDATED

    Source sequence(s)
    AA916456, AC133109, AK074131, DQ307286, DV080665, HY224642
    Consensus CDS
    CCDS74557.1
    UniProtKB/Swiss-Prot
    Q8TEJ3
    Related
    ENSP00000309186.6, ENST00000309415.8
    Conserved Domains (5) summary
    cd11785
    Location:827881
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    cd11925
    Location:467523
    SH3_SH3RF3_3; Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
    cd11928
    Location:197250
    SH3_SH3RF3_1; First Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
    cd11931
    Location:260314
    SH3_SH3RF3_2; Second Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
    cd00162
    Location:5698
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    109129205..109504635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511109.2XP_011509411.1  E3 ubiquitin-protein ligase SH3RF3 isoform X1

    Conserved Domains (5) summary
    cd11925
    Location:467523
    SH3_SH3RF3_3; Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
    cd11928
    Location:197250
    SH3_SH3RF3_1; First Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
    cd11931
    Location:260314
    SH3_SH3RF3_2; Second Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
    PLN02217
    Location:516649
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    cd16750
    Location:5398
    RING-HC_SH3RF3; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 3 (SH3RF3) and similar proteins
  2. XM_011511110.2XP_011509412.1  E3 ubiquitin-protein ligase SH3RF3 isoform X2

    Conserved Domains (3) summary
    cd11785
    Location:502556
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    cd11925
    Location:142198
    SH3_SH3RF3_3; Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
    PLN02217
    Location:191324
    PLN02217; probable pectinesterase/pectinesterase inhibitor
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