Format

Send to:

Choose Destination

CDKL4 cyclin dependent kinase like 4 [ Homo sapiens (human) ]

Gene ID: 344387, updated on 5-Sep-2021

Summary

Official Symbol
CDKL4provided by HGNC
Official Full Name
cyclin dependent kinase like 4provided by HGNC
Primary source
HGNC:HGNC:19287
See related
Ensembl:ENSG00000205111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CDKL4 in Genome Data Viewer
Location:
2p22.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (39168045..39248835, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (39395186..39471124, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr2.1553 Neighboring gene CRISPRi-validated cis-regulatory element chr2.1554 Neighboring gene Sharpr-MPRA regulatory region 10874 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 3 Neighboring gene RNA, U6 small nuclear 373, pseudogene Neighboring gene MAP4K3 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase-like 4
NP_001009565.1
NP_001333840.1
XP_011531117.1
XP_011531118.1
XP_011531119.1
XP_011531121.1
XP_016859470.1
XP_016859471.1
XP_016859473.1
XP_016859474.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009565.2NP_001009565.1  cyclin-dependent kinase-like 4 isoform 2

    See identical proteins and their annotated locations for NP_001009565.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate intron in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC079615, AY845084
    Consensus CDS
    CCDS33184.1
    UniProtKB/Swiss-Prot
    Q5MAI5
    Related
    ENSP00000368080.1, ENST00000378803.5
    Conserved Domains (2) summary
    cd07847
    Location:2286
    STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4
    pfam00069
    Location:4286
    Pkinase; Protein kinase domain
  2. NM_001346911.1NP_001333840.1  cyclin-dependent kinase-like 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC079615, AY847283
    Consensus CDS
    CCDS86834.1
    UniProtKB/Swiss-Prot
    Q5MAI5
    Related
    ENSP00000378476.3, ENST00000395035.3

RNA

  1. NR_144520.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon and lacks an alternate intron in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY845084, BC144460
  2. NR_144521.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' ends and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079615, AC092672

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    39168045..39248835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532817.2XP_011531119.1  cyclin-dependent kinase-like 4 isoform X2

    Conserved Domains (2) summary
    pfam00069
    Location:4245
    Pkinase; Protein kinase domain
    cl21453
    Location:2245
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011532816.2XP_011531118.1  cyclin-dependent kinase-like 4 isoform X1

    Conserved Domains (2) summary
    cd07847
    Location:2286
    STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4
    pfam00069
    Location:4286
    Pkinase; Protein kinase domain
  3. XM_017003981.2XP_016859470.1  cyclin-dependent kinase-like 4 isoform X1

    Conserved Domains (2) summary
    cd07847
    Location:2286
    STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4
    pfam00069
    Location:4286
    Pkinase; Protein kinase domain
  4. XM_017003982.1XP_016859471.1  cyclin-dependent kinase-like 4 isoform X1

    Conserved Domains (2) summary
    cd07847
    Location:2286
    STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4
    pfam00069
    Location:4286
    Pkinase; Protein kinase domain
  5. XM_011532815.3XP_011531117.1  cyclin-dependent kinase-like 4 isoform X6

    See identical proteins and their annotated locations for XP_011531117.1

    UniProtKB/Swiss-Prot
    Q5MAI5
    Conserved Domains (2) summary
    cd07847
    Location:2286
    STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4
    pfam00069
    Location:4286
    Pkinase; Protein kinase domain
  6. XM_011532819.2XP_011531121.1  cyclin-dependent kinase-like 4 isoform X3

    See identical proteins and their annotated locations for XP_011531121.1

    Conserved Domains (1) summary
    cl21453
    Location:2152
    PKc_like; Protein Kinases, catalytic domain
  7. XM_017003984.1XP_016859473.1  cyclin-dependent kinase-like 4 isoform X4

  8. XM_017003985.1XP_016859474.1  cyclin-dependent kinase-like 4 isoform X5

RNA

  1. XR_001738736.1 RNA Sequence

Support Center