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Rsf1 Repressor splicing factor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34370, updated on 4-Apr-2024

Summary

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Official Symbol
Rsf1provided by FlyBase
Official Full Name
Repressor splicing factor 1provided by FlyBase
Primary source
FLYBASE:FBgn0011305
Locus tag
Dmel_CG5655
See related
AllianceGenome:FB:FBgn0011305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5655; Dmel\CG5655; dRSF1; rox21; Rox21; ROX21; RSF1
Summary
Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome; regulation of mRNA 3'-end processing; and regulation of transcriptional start site selection at RNA polymerase II promoter. Located in nucleus. Is expressed in several structures, including adult head; embryonic brain; embryonic/larval midgut; embryonic/larval nervous system; and extended germ band embryo. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
31B1-31B1; 2-40 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10261795..10263554, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10261795..10263554, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ror Neighboring gene uncharacterized protein Neighboring gene Phosphatase and tensin homolog Neighboring gene REPTOR-binding partner Neighboring gene MOB kinase activator 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recognition of exonic splicing enhancer sequences by the Drosophila splicing repressor RSF1. Labourier E, et al. Nucleic Acids Res, 1999 Jun 1. PMID 10325428, Free PMC Article
  2. Novel Drosophila melanogaster genes encoding RRM-type RNA-binding proteins identified by a degenerate PCR strategy. Brand SF, et al. Gene, 1995 Mar 10. PMID 7890163
  3. Antagonism between RSF1 and SR proteins for both splice-site recognition in vitro and Drosophila development. Labourier E, et al. Genes Dev, 1999 Mar 15. PMID 10090730, Free PMC Article
  4. The SR proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila. Bennick RA, et al. Biochem Biophys Res Commun, 2019 Aug 27. PMID 31277943
  5. Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways. Gao X, et al. Dev Biol, 2000 May 15. PMID 10790335

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcriptional start site selection at RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
repressor splicing factor 1
Names
CG5655-PA
CG5655-PB
Rsf1-PA
Rsf1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10261795..10263554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273389.1 → NP_001260318.1  repressor splicing factor 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260318.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24424, Q24491, Q9VL15
    UniProtKB/TrEMBL
    Q8SYR3
    Conserved Domains (1) summary
    cd12373
    Location:11 → 82
    RRM_SRSF3_like; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins

  2. NM_057653.3 → NP_477001.2  repressor splicing factor 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477001.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24424, Q24491, Q9VL15
    UniProtKB/TrEMBL
    Q8SYR3
    Related
    FBpp0079668
    Conserved Domains (1) summary
    cd12373
    Location:11 → 82
    RRM_SRSF3_like; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24491.1 Q24491
Q8SYR3 Q8SYR3

Gene LinkOut

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