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ARHGAP40 Rho GTPase activating protein 40 [ Homo sapiens (human) ]

Gene ID: 343578, updated on 13-May-2022

Summary

Official Symbol
ARHGAP40provided by HGNC
Official Full Name
Rho GTPase activating protein 40provided by HGNC
Primary source
HGNC:HGNC:16226
See related
Ensembl:ENSG00000124143 AllianceGenome:HGNC:16226
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf95; dJ1100H13.4
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of actin filament polymerization and regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 12.2), esophagus (RPKM 3.7) and 4 other tissues See more
Orthologs
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Genomic context

See ARHGAP40 in Genome Data Viewer
Location:
20q11.23
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (38601809..38650653)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (40331453..40380311)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (37230452..37279296)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Ral GTPase activating protein non-catalytic subunit beta Neighboring gene ribosomal protein S3 pseudogene 2 Neighboring gene adipogenin Neighboring gene GINS complex subunit 2 (Psf2 homolog) pseudogene Neighboring gene GATA motif-containing MPRA enhancer 112/113 Neighboring gene VISTA enhancer hs2620

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ADIG

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activator activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 40
Names
rho-type GTPase-activating protein 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164431.3NP_001157903.2  rho GTPase-activating protein 40

    Status: INFERRED

    Source sequence(s)
    AL035419
    Related
    ENSP00000362442.5, ENST00000373345.9

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    38601809..38650653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    40331453..40380311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)