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ARHGAP40 Rho GTPase activating protein 40 [ Homo sapiens (human) ]

Gene ID: 343578, updated on 24-Nov-2020

Summary

Official Symbol
ARHGAP40provided by HGNC
Official Full Name
Rho GTPase activating protein 40provided by HGNC
Primary source
HGNC:HGNC:16226
See related
Ensembl:ENSG00000124143
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf95; dJ1100H13.4
Expression
Biased expression in skin (RPKM 12.2), esophagus (RPKM 3.7) and 4 other tissues See more
Orthologs

Genomic context

See ARHGAP40 in Genome Data Viewer
Location:
20q11.23
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (38601809..38650653)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (37230577..37279295)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Ral GTPase activating protein non-catalytic subunit beta Neighboring gene ribosomal protein S3 pseudogene 2 Neighboring gene adipogenin Neighboring gene GINS complex subunit 2 (Psf2 homolog) pseudogene Neighboring gene GATA motif-containing MPRA enhancer 112/113 Neighboring gene solute carrier family 32 member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ADIG

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 40
Names
rho-type GTPase-activating protein 40

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164431.2NP_001157903.1  rho GTPase-activating protein 40

    Status: INFERRED

    Source sequence(s)
    AL035419
    Related
    ENSP00000362442.4, ENST00000373345.8
    Conserved Domains (1) summary
    cl02570
    Location:319532
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    38601809..38650653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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