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FCRL6 Fc receptor like 6 [ Homo sapiens (human) ]

Gene ID: 343413, updated on 22-Sep-2022

Summary

Official Symbol
FCRL6provided by HGNC
Official Full Name
Fc receptor like 6provided by HGNC
Primary source
HGNC:HGNC:31910
See related
Ensembl:ENSG00000181036 MIM:613562; AllianceGenome:HGNC:31910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FcRH6
Summary
Enables MHC class II protein binding activity and protein phosphatase binding activity. Predicted to be involved in cell surface receptor signaling pathway. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen (RPKM 6.7), lung (RPKM 2.6) and 14 other tissues See more
Orthologs
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Genomic context

See FCRL6 in Genome Data Viewer
Location:
1q23.2
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (159800512..159816257)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (158937524..158953270)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159770302..159786047)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.9322 Neighboring gene Sharpr-MPRA regulatory region 9392 Neighboring gene uncharacterized LOC105371464 Neighboring gene SLAM family member 8 Neighboring gene small nucleolar RNA host gene 28 Neighboring gene small nucleolar RNA SNORD64

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of Fc receptor-like 6 (FCRL6) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16056

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MHC class II protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Fc receptor-like protein 6
Names
Fc receptor-like protein 7
IFGP6
IgSF type I transmembrane receptor
fc receptor homolog 6
fcR-like protein 6
leukocyte receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004310.3NP_001004310.2  Fc receptor-like protein 6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001004310.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer protein (isoform 1).
    Source sequence(s)
    AI631310, AK131201, AL590560, AY513661, DA959587
    Consensus CDS
    CCDS30912.1
    UniProtKB/Swiss-Prot
    Q6DN72, Q6ZNI1
    Related
    ENSP00000357086.3, ENST00000368106.4
    Conserved Domains (4) summary
    cd05753
    Location:1998
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:123198
    IG_like; Immunoglobulin like
    pfam13895
    Location:112200
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:206280
    Ig_3; Immunoglobulin domain
  2. NM_001284217.2NP_001271146.1  Fc receptor-like protein 6 isoform 2

    See identical proteins and their annotated locations for NP_001271146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus.
    Source sequence(s)
    AI631310, AK131201
    Consensus CDS
    CCDS60312.1
    UniProtKB/Swiss-Prot
    Q6DN72
    Related
    ENSP00000320625.6, ENST00000321935.10
    Conserved Domains (4) summary
    cd05753
    Location:26105
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:130205
    IG_like; Immunoglobulin like
    pfam13895
    Location:119207
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:213287
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    159800512..159816257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245128.5XP_005245185.1  Fc receptor-like protein 6 isoform X1

    Conserved Domains (4) summary
    cd05753
    Location:29108
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:133208
    IG_like; Immunoglobulin like
    pfam13895
    Location:122210
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:216290
    Ig_3; Immunoglobulin domain
  2. XM_005245131.4XP_005245188.1  Fc receptor-like protein 6 isoform X4

    Related
    ENSP00000340949.5, ENST00000339348.9
    Conserved Domains (4) summary
    cd05753
    Location:29108
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:133208
    IG_like; Immunoglobulin like
    pfam13895
    Location:122210
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:216290
    Ig_3; Immunoglobulin domain
  3. XM_047419607.1XP_047275563.1  Fc receptor-like protein 6 isoform X6

  4. XM_011509480.3XP_011507782.1  Fc receptor-like protein 6 isoform X2

    Conserved Domains (4) summary
    cd05753
    Location:26105
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:130205
    IG_like; Immunoglobulin like
    pfam13895
    Location:119207
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:213287
    Ig_3; Immunoglobulin domain
  5. XM_047419606.1XP_047275562.1  Fc receptor-like protein 6 isoform X6

  6. XM_005245129.5XP_005245186.1  Fc receptor-like protein 6 isoform X3

    Conserved Domains (5) summary
    cd05753
    Location:1493
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:118193
    IG_like; Immunoglobulin like
    pfam11377
    Location:304342
    DUF3180; Protein of unknown function (DUF3180)
    pfam13895
    Location:107195
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:201275
    Ig_3; Immunoglobulin domain
  7. XM_011509481.3XP_011507783.1  Fc receptor-like protein 6 isoform X5

    Conserved Domains (4) summary
    cd05753
    Location:29108
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:133208
    IG_like; Immunoglobulin like
    pfam13895
    Location:122210
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:216290
    Ig_3; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    158937524..158953270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)