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SoYb Sister of Yb [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34331, updated on 4-Apr-2024

Summary

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Official Symbol
SoYbprovided by FlyBase
Official Full Name
Sister of Ybprovided by FlyBase
Primary source
FLYBASE:FBgn0051755
Locus tag
Dmel_CG31755
See related
AllianceGenome:FB:FBgn0051755
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31755; CG5831; Dmel\CG31755; soyb
Summary
Predicted to enable helicase activity. Involved in negative regulation of transposition, RNA-mediated. Located in Yb body. Is expressed in spermatozoon. Orthologous to human TDRD12 (tudor domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
30F5-30F5; 2-38 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9996706..10002736, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9996706..10002736, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L13 Neighboring gene long non-coding RNA:CR13130 Neighboring gene big brain Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44873 Neighboring gene Nucleosome-destabilizing factor Neighboring gene Translocation protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Retrovirus reactivation in CHMP2BIntron5 models of frontotemporal dementia. Fort-Aznar L, et al. Hum Mol Genet, 2020 Sep 29. PMID 32628265, Free PMC Article
  2. Requirements for multivalent Yb body assembly in transposon silencing in Drosophila. Hirakata S, et al. EMBO Rep, 2019 Jul. PMID 31267711, Free PMC Article
  3. piRNAs as Modulators of Disease Pathogenesis. Rayford KJ, et al. Int J Mol Sci, 2021 Feb 27. PMID 33673453, Free PMC Article
  4. The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster. Szakmary A, et al. J Cell Biol, 2009 May 18. PMID 19433453, Free PMC Article
  5. Armitage determines Piwi-piRISC processing from precursor formation and quality control to inter-organelle translocation. Yamashiro H, et al. EMBO Rep, 2020 Feb 5. PMID 31833223, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila TUDOR domain-containing proteins interact with Vreteno and the Tdrd12 family, essential primary piRNA pathway factors
    Title: A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in germ-line stem cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in primary piRNA processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in primary piRNA processing IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in secondary piRNA processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Yb body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Yb body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sister of Yb
Names
CG31755-PB
CG31755-PC
SoYb-PB
SoYb-PC
NP_001245959.1
NP_609335.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9996706..10002736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259030.2 → NP_001245959.1  sister of Yb, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245959.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E0R964, Q9VL52
    Conserved Domains (3) summary
    COG0513
    Location:475 → 877
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:927 → 1043
    TUDOR; Tudor domain
    cl21455
    Location:480 → 646
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_135491.5 → NP_609335.3  sister of Yb, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609335.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E0R964, Q9VL52
    Conserved Domains (3) summary
    COG0513
    Location:475 → 877
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:927 → 1043
    TUDOR; Tudor domain
    cl21455
    Location:480 → 646
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VL52.3 Q9VL52

Gene LinkOut

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