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OR2W3 olfactory receptor family 2 subfamily W member 3 [ Homo sapiens (human) ]

Gene ID: 343171, updated on 2-Oct-2018

Summary

Official Symbol
OR2W3provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily W member 3provided by HGNC
Primary source
HGNC:HGNC:15021
See related
Ensembl:ENSG00000238243 MIM:616729; Vega:OTTHUMG00000040204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR2W3P; OR2W8P; OST718
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See OR2W3 in Genome Data Viewer
Location:
1q44
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (247895587..247896531)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (248058889..248059833)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 11 subfamily L member 1 Neighboring gene tripartite motif containing 58 Neighboring gene olfactory receptor family 2 subfamily T member 8 Neighboring gene olfactory receptor family 2 subfamily AJ member 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Olfactory Signaling Pathway, organism-specific biosystem (from REACTOME)
    Olfactory Signaling Pathway, organism-specific biosystemMammalian Olfactory Receptor (OR) genes were discoved in rats by Linda Buck and Richard Axel, who predicted that odorants would be detected by a large family of G protein-coupled receptors (GPCRs) th...
  • Olfactory transduction, organism-specific biosystem (from KEGG)
    Olfactory transduction, organism-specific biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
  • Olfactory transduction, conserved biosystem (from KEGG)
    Olfactory transduction, conserved biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
olfactory receptor 2W3
Names
olfactory receptor 2W8
olfactory receptor OR1-49
olfactory receptor, family 2, subfamily W, member 3 pseudogene
olfactory receptor, family 2, subfamily W, member 8 pseudogene

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053132.1 RefSeqGene

    Range
    5001..5945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001957.2NP_001001957.2  olfactory receptor 2W3

    See identical proteins and their annotated locations for NP_001001957.2

    Status: REVIEWED

    Source sequence(s)
    AB065949
    Consensus CDS
    CCDS31099.1
    UniProtKB/Swiss-Prot
    Q7Z3T1
    Related
    ENSP00000353516.3, OTTHUMP00000038055, ENST00000360358.3, OTTHUMT00000096861
    Conserved Domains (2) summary
    pfam00001
    Location:41290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35308
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    247895587..247896531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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