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PRAMEF10 PRAME family member 10 [ Homo sapiens (human) ]

Gene ID: 343071, updated on 10-Dec-2024

Summary

Official Symbol
PRAMEF10provided by HGNC
Official Full Name
PRAME family member 10provided by HGNC
Primary source
HGNC:HGNC:27997
See related
Ensembl:ENSG00000187545 AllianceGenome:HGNC:27997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in several processes, including negative regulation of DNA-templated transcription; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward liver (RPKM 6.5) See more
Orthologs
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Genomic context

See PRAMEF10 in Genome Data Viewer
Location:
1p36.21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (12892896..12898270, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (12436863..12442237, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (13409128..13414502)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:12919058-12920257 Neighboring gene PRAME family member 2 Neighboring gene PRAME family member 4 Neighboring gene PRAME family member 7 Neighboring gene RNA, U6 small nuclear 1072, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC138413, MGC138415

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039361.4NP_001034450.3  PRAME family member 10

    Status: VALIDATED

    Source sequence(s)
    AC245034
    Consensus CDS
    CCDS41255.1
    UniProtKB/Swiss-Prot
    O60809, Q2M1V2
    Related
    ENSP00000235347.4, ENST00000235347.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    12892896..12898270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_012132914.1 Reference GRCh38.p14 PATCHES

    Range
    74409..79783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    12436863..12442237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)