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NANOS3 nanos C2HC-type zinc finger 3 [ Homo sapiens (human) ]

Gene ID: 342977, updated on 1-Mar-2024

Summary

Official Symbol
NANOS3provided by HGNC
Official Full Name
nanos C2HC-type zinc finger 3provided by HGNC
Primary source
HGNC:HGNC:22048
See related
Ensembl:ENSG00000187556 MIM:608229; AllianceGenome:HGNC:22048
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOS3; NANOS1L; ZC2HC12C
Summary
Predicted to enable mRNA binding activity. Involved in germ cell development; negative regulation of translation; and positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 1.4), brain (RPKM 1.0) and 7 other tissues See more
Orthologs
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Genomic context

See NANOS3 in Genome Data Viewer
Location:
19p13.12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (13862036..13880757)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (13988190..14006913)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13972850..13991571)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14143 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10212 Neighboring gene miR-23a/27a/24-2 cluster host gene Neighboring gene CRISPRi-validated cis-regulatory element chr19.2258 Neighboring gene microRNA 27a Neighboring gene microRNA 23a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14144 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:13958655-13958860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13964511-13965456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13975386-13976271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14148 Neighboring gene microRNA 181c Neighboring gene microRNA 181d Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13993737-13994582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14000391-14000892 Neighboring gene break repair meiotic recombinase recruitment factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10218 Neighboring gene coiled-coil and C2 domain containing 1A Neighboring gene MPRA-validated peak3378 silencer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC120114

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in oogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in P-body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098622.3NP_001092092.1  nanos homolog 3

    See identical proteins and their annotated locations for NP_001092092.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    AC020916, KF511254
    Consensus CDS
    CCDS42511.1
    UniProtKB/Swiss-Prot
    P60323, Q495E5
    Related
    ENSP00000341992.4, ENST00000339133.6
    Conserved Domains (2) summary
    pfam05741
    Location:77129
    zf-nanos; Nanos RNA binding domain
    cl25865
    Location:2474
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)

RNA

  1. NR_146095.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC020916, CK821051
    Related
    ENST00000591727.1
  2. NR_146096.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC020916, BM702754, CK821051
  3. NR_146097.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC020916, CK821051

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    13862036..13880757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160022.1 Reference GRCh38.p14 PATCHES

    Range
    73877..92598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    13988190..14006913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)